Dantrolene Flashcards
1
Q
Dantrolene Trade Name
A
Dantrium
2
Q
Dantrolene MOA
A
Dissociates the excitation-contraction coupling in skeletal muscle, likely by interfering with Ca release
3
Q
Malignant Hyperthermia MOA
A
Elevated myoplasmic calcium activates acute cellular catabolic processes leading to HM
4
Q
Dantrolene Indications
A
Malignant hyperthermia crisis
5
Q
Malignant Hyperthermia Presentation
A
Muscle contractions and rigidity causing increased body temperature
Caused by inhaled anesthetics/succinylcholine
6
Q
Dantrolene Dosing
A
2.5 mg/kg rapid push
Up to 10 mg/kg
7
Q
Dantrolene Preparation
A
60 mL of sterile water/ 20mg vial
Protected from direct light
