Bivalrudin

Question 1

Bivalrudin Trade Name

Answer 1

Angiomax

Question 2

Bivalrudin Indications

Answer 2

Anticoagulant for PTCA and PCT
Alternative to heparin for HIT

Question 3

Bivalrudin Drug Class

Answer 3

Direct thrombin inhibitor
Anticoagulant

Question 4

Bivalrudin Dosing

Answer 4

0.75 mg/kg initial bolus
1.75 mg/kg/h infusion
0.3 mg/kg maintenance bolus

Question 5

Bivalrudin Contraindications

Answer 5

Major active bleeding

Question 6

Bivalrudin MOA

Answer 6

Inhibits thrombin by binding to it in two places

Question 7

Bivalrudin Adverse Effects

Answer 7

Hemorrhage
No antidote
Severe renal impairment

Question 8

Bivalrudin and Heparin

Answer 8

Alternative for CPB and ECMO to prevent heparin resistance or HIT

Question 9

Bivalrudin and CPB

Answer 9

50 mg bolus to circuit
1 mg/kg loading dose
2.5 mg/kg/h infusion
0.1-0.5 mg/kg maintenance dose

Question 10

Bivalrudin and ECMO

Answer 10

0.025 to 2.5 mg/kg/h infusion rates are common for maintaining ECMO anticoagulation levels