Desmopressin

Question 1

Desmopressin Trade Name

Answer 1

DDAVP

Question 2

Desmopressin Drug Class

Answer 2

Synthetic analog of vasopressin, antidiuretic hormone

Question 3

Desmopressin Indications

Answer 3

Cranial diabetes Insipidus
mild to moderate von Willebrand’s Disease
Hemophilia A - factor VIII coagulant levels >5%

Question 4

Desmopressin Contraindications

Answer 4

Moderate to severe renal impairment
Hyponatremia

Question 5

Desmopressin Dosing

Answer 5

4 mcg/mL vials
0.3 mcg/kg over 15-20 min

Question 6

Desmopressin and CPB

Answer 6

Evidence shows an increase in von Willebrand factor and factor VIII

Question 7

Desmopressin MOA

Answer 7

Increase cAMP in renal tubules, increasing water permeability, decreasing urine volume

Question 8

Desmopressin and Factors

Answer 8

The cascade that produces cAMP also induces exocytosis of von Willebrand factor, factor VIII. and alpha granules of platelets

Question 9

Desmopressin Preparation

Answer 9

Intranasal route
Intravenous route