Antithrombin III Flashcards
1
Q
ATIII Trade Name
A
Thrombate
2
Q
ATIII Indications
A
ATIII deficiency
Heparin resistance
3
Q
ATIII Dosing
A
units (UI) = ([desired-baseline ATIII level]*kg)/1.4
4
Q
ATIII Contraindications
A
JW patients
5
Q
ATIII MOA
A
ATIII covalently bond to thrombin, inactivating it
6
Q
ATIII Drug Class
A
Protein
Thrombin inhibitor
7
Q
ATIII Preparation
A
500 IU
1000 IU
8
Q
ATIII and pre-CPB
A
Initial loading dose is standard 500 UI for adults, though may be calculated
Additional heparin must be given, 5000-10000 units
Maintenance may be required on CPB
9
Q
ATIII Considerations
A
Expensive
