Amicar

Question 1

AMICAR Generic Name

Answer 1

Aminocaproic acid

Question 2

AMICAR MOA

Answer 2

Inhibition of plasminogen activators to produce fibrinolysis-inhibitory effects

Question 3

AMICAR Indications

Answer 3

Enhances hemostasis when fibrinolysis contributes to bleeding post cardiac procedures

Question 4

AMICAR Contraindications

Answer 4

Active intravascular clotting process
Concern of DIC or primary fibrinolysis
Factor IX Complex concentrates - risk of thrombosis

Question 5

Difference between primary fibrinolysis and DIC

Answer 5

Platelet count decreased in DIC, not in primary fibrinolysis
Protamine paracoagulation test positive in DIC, negative in primary fibrinolysis
Euglobin clot lysis test abnormal in primary fibrinolysis, normal in DIC

Question 6

AMICAR Risk Factors

Answer 6

Upper urinary tract bleeding
Possible damage to muscle tissue with excessive doses, causes increased CKD levels

Question 7

AMICAR Dosing

Answer 7

5g bolus, followed by 1.25g/hr for 8 hours or until bleeding stopped
Excessive dosing is counterintuitive, 20g is a recommended limit but with no research support

Question 8

AMICAR Drug Class

Answer 8

Antifibrinolytic