Prostaglandin Analogs Flashcards
1
Q
Generics/Brands
A
- Latanoprost (Xalatan)
- Travoprost (Travatan, Travatan Z)
- Tafluprost (Zioptan)
- Unoprostone (Rescula)
- Bimatoprost (Lumigan)
2
Q
MOA
A
Increase uveoscleral and/or trabecular outflow
3
Q
Indications
A
- Reduce intraocular pressure by 25% to 33%
- Open-angle glaucoma (first-line reduction of IOP)
4
Q
Prostaglandin Analogs are considered to be a ________
A
Prodrug - body metabolizes it to become active (metabolized to PGF2a)
5
Q
Warning/precautions
A
Periocular hyperpigmentation (iris changes color) - drug binds with melanin (Latanoprost)
6
Q
Adverse Reactions
A
- Macular edema
- Conjunctival injection
- Increased eyelash growth
- Uveitis
- Herpes virus activation
