Aminoglycosides

Question 1

Generics/Brands

Answer 1

1. Gentamicin ointment
2. Tobramycin ointment (Tobrex)
3. Tobramycin/dexamethasone ophthalmic suspension (Tobradex)
4. Tobramycin/fluorometholone acetate (Tobraflex)

Question 2

MOA

Answer 2

• Binds ribosomal RNA leading to translation disruption and inhibition of translocation
• Bactericidal
• Broad spectrum inhibiting:
  
  1. Staph
  2. Strep
  3. Gram (-) including Ps. aeru

Question 3

What can you use with organisms that are resistance to Gentamicin?

Answer 3

Tobramycin

Question 4

Indications

Answer 4

• Topical treatment of bacterial infections

- Tobradex (brand name) - for inflammatory ocular conditions where bacteria or risk of bacteria is present

Question 5

Contraindications

Answer 5

Hypersensitivity

Question 6

Contraindications for Tobradex (brand name), specifically

Answer 6

• Ocular fungal or viral infections

- Mycobacterial infection

Question 7

Generally, you shouldn’t mix steroids with what type of drug?

Answer 7

Anti-fungals

Question 8

Adverse reactions

Answer 8

• Corneal ulcers, burning, irritation, conjunctivitis, hyperemia
• Rare: thrombocytopenic purpura hallucinations