Carbonic Anhydrase Inhibitors

Question 1

Oral Carbonic Anhydrase Inhibitors

Answer 1

Acetazolamide (Diamox)

Question 2

Topical Carbonic Anhydrase Inhibitors

Answer 2

• Dorzolamide (Trusopt)
• Dorzolamide, timolol (Cosopt)
• Brinzolamide (Adopt)

Question 3

MOA

Answer 3

• Inhibit CA-II

- Decrease aqueous humor secretion by decreasing formation of bicarb ions (reduces sodium and fluid transport)

Question 4

Indications

Answer 4

• Decrease IOP by 15-20%

- Low on the list of Rx to pts, use if patients don’t respond well to other medications