Lifitegrast

Question 1

Brand name

Answer 1

Xiidra

Question 2

MOA

Answer 2

• Ligand intercellular adhesion molecule (ICAM-1) binds LFA-1 which activates T-cells and cytokines
• ICAM-1 appears to be over expressed in dry eye disease
• Blocking ICAM-1 binding to LFA-1 may help prevent inflammatory cascade

Question 3

Common adverse reactions

Answer 3

Site irritation, dysgeusia (bad taste in your mouth), reduced visual acuity

Question 4

Indications

Answer 4

Dry eyes

Question 5

Less common adverse reactions

Answer 5

Blurred vision, conjunctival hyperemia, eye irritation/discharge/discomfort, headache, increased lacrimation, sinusitis

Question 6

Application

Answer 6

• Remove contacts prior to administration (can replace after 15 minutes)