Fluoroquinolones

Question 1

Generic names/Brand names

Answer 1

1. Besifloxacin (Besivance)
2. Ciprofloxacin ointment (Ciloxan) - common
3. Gatifloxacin (Zymar, Zymaxid)
4. Levofloxacin (Quixin) - conjunctivitis
5. Levofloxacin (Iquix) - corneal ulcers
6. Ofloxacin (Floxin, Ocuflox) - common

Question 2

MOA

Answer 2

• Broad spectrum - affects gram +, gram -, and anaerobes by inhibiting DNA gyrase of:
  
  1. Staph
  2. Strep,
  3. Enterobacter
  4. H.flu,
  5. Ps. aero
  6. Propionibacterium acnes

Question 3

Indications

Answer 3

1. Conjunctivitis

2. Corneal ulcers (patients who wear contacts - likely Pseudomonas)

Question 4

Contraindications

Answer 4

Hypersensitivity

Question 5

Adverse reactions

Answer 5

Transient ocular burning/discomfort, foreign body sensation, photophobia, blurred vision, tearing, dryness, eye pain

Question 6

Gatifloxacin inhibits which bacteria

Answer 6

1. Staph
2. Strep
3. H. flu

Question 7

Moxifloxacin inhibits which bacteria

Answer 7

1. Staph
2. Strep
3. Enterobacter
4. H. flu
5. Propionibacterium acnes