Progesterones

Question 1

Micronized progesterone

Answer 1

Class: Natural progesterone

Mechanism of action: Binds to PR, decreased first pass metabolism and increased dissolution due to micronization

Therapeutic uses: contraception and hormone replacement therapy

Toxicities: Fatigue and drowsiness

Other:  Contraindicated in:
thrombotic event or history of one
liver disease
undiagnosed vaginal bleeding
pregnancy (causes atrophy of uterus causing birth defects)

Question 2

Transvaginal progesterone

Answer 2

Class: Natural progesterone

Mechanism of action: Binds to PR, vaginal gel that has uterine effects without first pass metabolism and minimal systemic SEs

Therapeutic uses: contraception and hormone replacement therapy

Toxicities: Fatigue and drowsiness

Other:  Contraindicated in:
thrombotic event or history of one
liver disease
undiagnosed vaginal bleeding
pregnancy (causes atrophy of uterus causing birth defects)

Question 3

Medroxyprogesterone

Answer 3

Class: Synthetic progesterone

Mechanism of action: Binds to PR

Therapeutic uses: contraception and hormone replacement therapy

Toxicities: edema, bloating, and less commonly strong androgenic effects (hirsuitism, acne)
Also anxiety, irritability, depression, muscle pain, increased likelihood of thrombotic event (PE)

Other:  Contraindicated in:
thrombotic event or history of one
liver disease
undiagnosed vaginal bleeding
pregnancy (causes atrophy of uterus causing birth defects)

Question 4

Norethindrone

Answer 4

Class: Synthetic progesterone

Mechanism of action: Binds to PR

Therapeutic uses: contraception and hormone replacement therapy

Toxicities: edema, bloating, and less commonly strong androgenic effects (hirsuitism, acne)
Also anxiety, irritability, depression, muscle pain, increased likelihood of thrombotic event (PE)

Other:  Contraindicated in:
thrombotic event or history of one
liver disease
undiagnosed vaginal bleeding
pregnancy (causes atrophy of uterus causing birth defects)

Question 5

Norgestrel

Answer 5

Class: Synthetic progesterone

Mechanism of action: Binds to PR

Therapeutic uses: contraception and hormone replacement therapy

Toxicities: edema, bloating, and less commonly strong androgenic effects (hirsuitism, acne)
Also anxiety, irritability, depression, muscle pain, increased likelihood of thrombotic event (PE)

Other:  Contraindicated in:
thrombotic event or history of one
liver disease
undiagnosed vaginal bleeding
pregnancy (causes atrophy of uterus causing birth defects)

Question 6

Megestrol

Answer 6

Class: Synthetic progesterone

Mechanism of action: Binds to PR

Therapeutic uses: contraception and hormone replacement therapy

Toxicities: edema, bloating, and less commonly strong androgenic effects (hirsuitism, acne)
Also anxiety, irritability, depression, muscle pain, increased likelihood of thrombotic event (PE)

Other:  Contraindicated in:
thrombotic event or history of one
liver disease
undiagnosed vaginal bleeding
pregnancy (causes atrophy of uterus causing birth defects)