Biological Response Modifiers Flashcards

1
Q

Ethanercept

A

Class: Biologic Response modifier

Mech: Blocks binding of TNF to TNF receptors

Thera: Rheumatoid

Tox: N/A

Misc: Twice weekly SC injections.

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2
Q

Infliximab

A

Class: Biologic Response modifier

Mech: Blocks binding of TNF to TNF receptors

Thera: Rheumatoid

Tox: Antigenic response to murine monoclonal Ab

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3
Q

Adalimumab

A

Class: Biologic Response modifier

Mech: Blocks binding of TNF to TNF receptors

Thera: Rheumatoid

Tox: N/A

Misc: Fully human so no antigenic response
Twice monthly injections

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4
Q

Golimumab

A

Class: Biologic Response modifier

Mech: Blocks binding of TNF to TNF receptors

Thera: Rheumatoid

Tox: Risk of serious infections

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5
Q

Certolizumab

A

Class: Biologic Response modifier

Mech: Blocks binding of TNF to TNF receptors

Thera: Rheumatoid

Tox: Risk of serious infections

Misc: Conjugated to Polyethylene glycol for stabalization

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6
Q

Anakinra

A

Class: Biologic Response modifier

Mech: IL-1 receptor antagonist

Thera: Rheumatoid

Tox: N/A

Misc: Short (6hr) halflife therefore daily treatment with high doses is necessary

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7
Q

Tocilizumab

A

Class: biologic response modifier

Mech: IL-6 Receptor antagonist

Thera: Rheumatoid

Tox: N/A

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8
Q

Rituximab

A

Class: Biologic Response modifier

Mech: Anti-CD20 mAB reducing circulating B cells.

Thera: Rheumatoid

Tox: Infections, hypersensitivity rxns

Misc: Used for rheumatoid refractory to TNF alpha inhibitor listed above

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9
Q

Abatacept

A

Class: Biologic Response modifier

Mech: Inhibits T-cell activation and induces T-cell apoptosis.

Thera: Rheumatoid

Tox: Headaches, infections

Misc: Used for patients for rheumatoid refractory to MTX or TNF-alpha inhibitors

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