Biological Response Modifiers

Question 1

Ethanercept

Answer 1

Class: Biologic Response modifier

Mech: Blocks binding of TNF to TNF receptors

Thera: Rheumatoid

Tox: N/A

Misc: Twice weekly SC injections.

Question 2

Infliximab

Answer 2

Class: Biologic Response modifier

Mech: Blocks binding of TNF to TNF receptors

Thera: Rheumatoid

Tox: Antigenic response to murine monoclonal Ab

Question 3

Adalimumab

Answer 3

Class: Biologic Response modifier

Mech: Blocks binding of TNF to TNF receptors

Thera: Rheumatoid

Tox: N/A

Misc: Fully human so no antigenic response
Twice monthly injections

Question 4

Golimumab

Answer 4

Class: Biologic Response modifier

Mech: Blocks binding of TNF to TNF receptors

Thera: Rheumatoid

Tox: Risk of serious infections

Question 5

Certolizumab

Answer 5

Class: Biologic Response modifier

Mech: Blocks binding of TNF to TNF receptors

Thera: Rheumatoid

Tox: Risk of serious infections

Misc: Conjugated to Polyethylene glycol for stabalization

Question 6

Anakinra

Answer 6

Class: Biologic Response modifier

Mech: IL-1 receptor antagonist

Thera: Rheumatoid

Tox: N/A

Misc: Short (6hr) halflife therefore daily treatment with high doses is necessary

Question 7

Tocilizumab

Answer 7

Class: biologic response modifier

Mech: IL-6 Receptor antagonist

Thera: Rheumatoid

Tox: N/A

Question 8

Rituximab

Answer 8

Class: Biologic Response modifier

Mech: Anti-CD20 mAB reducing circulating B cells.

Thera: Rheumatoid

Tox: Infections, hypersensitivity rxns

Misc: Used for rheumatoid refractory to TNF alpha inhibitor listed above

Question 9

Abatacept

Answer 9

Class: Biologic Response modifier

Mech: Inhibits T-cell activation and induces T-cell apoptosis.

Thera: Rheumatoid

Tox: Headaches, infections

Misc: Used for patients for rheumatoid refractory to MTX or TNF-alpha inhibitors