Biological Response Modifiers Flashcards
Ethanercept
Class: Biologic Response modifier
Mech: Blocks binding of TNF to TNF receptors
Thera: Rheumatoid
Tox: N/A
Misc: Twice weekly SC injections.
Infliximab
Class: Biologic Response modifier
Mech: Blocks binding of TNF to TNF receptors
Thera: Rheumatoid
Tox: Antigenic response to murine monoclonal Ab
Adalimumab
Class: Biologic Response modifier
Mech: Blocks binding of TNF to TNF receptors
Thera: Rheumatoid
Tox: N/A
Misc: Fully human so no antigenic response
Twice monthly injections
Golimumab
Class: Biologic Response modifier
Mech: Blocks binding of TNF to TNF receptors
Thera: Rheumatoid
Tox: Risk of serious infections
Certolizumab
Class: Biologic Response modifier
Mech: Blocks binding of TNF to TNF receptors
Thera: Rheumatoid
Tox: Risk of serious infections
Misc: Conjugated to Polyethylene glycol for stabalization
Anakinra
Class: Biologic Response modifier
Mech: IL-1 receptor antagonist
Thera: Rheumatoid
Tox: N/A
Misc: Short (6hr) halflife therefore daily treatment with high doses is necessary
Tocilizumab
Class: biologic response modifier
Mech: IL-6 Receptor antagonist
Thera: Rheumatoid
Tox: N/A
Rituximab
Class: Biologic Response modifier
Mech: Anti-CD20 mAB reducing circulating B cells.
Thera: Rheumatoid
Tox: Infections, hypersensitivity rxns
Misc: Used for rheumatoid refractory to TNF alpha inhibitor listed above
Abatacept
Class: Biologic Response modifier
Mech: Inhibits T-cell activation and induces T-cell apoptosis.
Thera: Rheumatoid
Tox: Headaches, infections
Misc: Used for patients for rheumatoid refractory to MTX or TNF-alpha inhibitors