COX 2 inhibitors

Question 1

Celocoxib

Answer 1

Class: COX 2 inhibitor

Mech: Selectively inhibits COX 2 bc too bulky to interact with 1

Thera: Same anti-inflammatory, antipyretic, and analgesic effects as NSAIDs

Tox: Less GI toxicity than traditional NSAIDs

Misc: Contraindicated in patients with heart problems/pregnancy

Question 2

Etoricoxib

Answer 2

Class: COX 2 inhibitor

Mech: Selectively inhibits COX 2 bc too bulky to interact with 1

Thera: Same anti-inflammatory, antipyretic, and analgesic effects as NSAIDs

Tox: Less GI toxicity than traditional NSAIDs

Misc: Contraindicated in patients with heart problems/pregnancy