Estrogens Flashcards

1
Q

Estradiol (valerate, cypionate)

A

Class: Estradiol esters (steroidal)

Mechanism of action: Absorbed via skin, mucus membranes, GI tract. Body Wide distribution via SHBG.

Therapeutics: Contraception, Primary Hypogonadism, Post-menopausal Hormone Replacement Therapy

Toxicities: Weight gain, Hypertension, Increased likelihood of breast, cervical, endometrial cancer. Increased likelihood of thrombotic event.
Also will cause nausea, breast pain, vaginal bleeding, headache

Contraindications: Breast/endometrial cancer, endometriosis, undiagnosed vaginal bleeding, pregnancy, thrombotic disease, hypertension, liver disease, family history of breast cancer, endometrial cancer.

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2
Q

Estrone Sulfate

A

Class: Estradiol esters (steroidal)

Mechanism of action: Absorbed via skin, mucus membranes, GI tract. Body Wide distribution via SHBG.

Therapeutics: Contraception, Primary Hypogonadism, Post-menopausal Hormone Replacement Therapy

Toxicities: Weight gain, Hypertension, Increased likelihood of breast, cervical, endometrial cancer. Increased likelihood of thrombotic event.
Also will cause nausea, breast pain, vaginal bleeding, headache

Contraindications: Breast/endometrial cancer, endometriosis, undiagnosed vaginal bleeding, pregnancy, thrombotic disease, hypertension, liver disease, family history of breast cancer, endometrial

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3
Q

Equilin Sulfate

A

Class: Estradiol esters (steroidal)

Mechanism of action: Absorbed via skin, mucus membranes, GI tract. Body Wide distribution via SHBG.

Therapeutics: Contraception, Primary Hypogonadism, Post-menopausal Hormone Replacement Therapy

Toxicities: Weight gain, Hypertension, Increased likelihood of breast, cervical, endometrial cancer. Increased likelihood of thrombotic event.
Also will cause nausea, breast pain, vaginal bleeding, headache

Contraindications: Breast/endometrial cancer, endometriosis, undiagnosed vaginal bleeding, pregnancy, thrombotic disease, hypertension, liver disease, family history of breast cancer, endometrial

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4
Q

Quinestrol

A

Class: Estradiol esters (steroidal)

Mechanism of action: Absorbed via skin, mucus membranes, GI tract. Body Wide distribution via SHBG.

Therapeutics: Contraception, Primary Hypogonadism, Post-menopausal Hormone Replacement Therapy

Toxicities: Weight gain, Hypertension, Increased likelihood of breast, cervical, endometrial cancer. Increased likelihood of thrombotic event.
Also will cause nausea, breast pain, vaginal bleeding, headache

Contraindications: Breast/endometrial cancer, endometriosis, undiagnosed vaginal bleeding, pregnancy, thrombotic disease, hypertension, liver disease, family history of breast cancer, endometrial

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5
Q

Ethinyl estradiol

A

Class: Alkyl estrogen

Mechanism of action: Absorbed via skin, mucus membranes, GI tract. Body Wide distribution via SHBG.

Therapeutics: Contraception, Primary Hypogonadism, Post-menopausal Hormone Replacement Therapy

Toxicities: Weight gain, Hypertension, Increased likelihood of breast, cervical, endometrial cancer. Increased likelihood of thrombotic event.
Also will cause nausea, breast pain, vaginal bleeding, headache

Contraindications: Breast/endometrial cancer, endometriosis, undiagnosed vaginal bleeding, pregnancy, thrombotic disease, hypertension, liver disease, family history of breast cancer, endometrial

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6
Q

Mestranol

A

Class: Alkyl Estrol

Mechanism of action: Absorbed via skin, mucus membranes, GI tract. Body Wide distribution via SHBG.

Therapeutics: Contraception, Primary Hypogonadism, Post-menopausal Hormone Replacement Therapy

Toxicities: Weight gain, Hypertension, Increased likelihood of breast, cervical, endometrial cancer. Increased likelihood of thrombotic event.
Also will cause nausea, breast pain, vaginal bleeding, headache

Contraindications: Breast/endometrial cancer, endometriosis, undiagnosed vaginal bleeding, pregnancy, thrombotic disease, hypertension, liver disease, family history of breast cancer, endometrial

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7
Q

Diethylstilbistrol

A

Class: Non-steroidal synthetic estrogen

Toxicities: Increases likelihood of clear cell carcinoma of vagina and cervix

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