Antiplatelets

Question 1

Aspirin

Answer 1

Class: Antiplatelet

Mech: Irreversibly inhibits platelets, preventing thromboxane A2 formation

Thera: Often as baby aspirin to prevent and treat MI and stroke

Question 2

Dipyridamole

Answer 2

Class: Antiplatelet

Mech: PDE inhibitor which increases platelet cAMP

Thera: Weak antiplatelet effect

Misc: Given parenterally

Question 3

Clopidogrel

Answer 3

Class: Antiplatelet

Mech: Inhibits platelet ADP receptors

Thera: Prevent and treat ACS, stroke, PVD, angina, stent

Tox: Bleeding, TTP (rare)

Misc: Reversed by platelet transfusion

Question 4

Abciximab

Answer 4

Class: Antiplatelet

Mech: Monoclonal ab against GPIIb/IIIa

Thera: N/a

Tox: May elicit an immune response

Misc: Given parenterally

Question 5

Eptifibatide

Answer 5

Class: Antiplatelet

Mech: Fibrinogen analog which competes with endogenous fibrinogen for IIb/IIIa

Thera: N/a

Tox: Bleeding, ACS, PCI, thrombocytopenia

Misc: Given parenterally

Question 6

Tirofiban

Answer 6

Class: Antiplatelet

Mech: Fibrinogen analog which competes with endogenous fibrinogen and for IIb/IIIa

Thera: N/a

Tox: Bleeding, ACS, NSTE

Misc: Given parenterally; immediate effect