Prochlorperazine (Stemetil)

Question 1

Stemetil
Type

Answer 1

Phenothiazine antiemetic

Question 2

Stemetil
Presentations

Answer 2

12.5mg in 1ml - ampoule

Question 3

Stemetil
Actions

Answer 3

Acts on several neurotransmitter systems:
1. anti dopamine actions
2. alpha-adrenergic antagonism
3. potentiates noradrenaline
4. weak anticholinergic and antihistamine effects
5. weak serotonin antagonism
Onset IM: limited data
Duration IM: limited data - likely to be prolonged

Question 4

Stemetil
Uses

Answer 4

For the treatment (only) of nausea and vomiting from a variety of vestibular causes, including motion sickness, migraine, vertigo and labyrinthitis.

Question 5

Stemetil
Adverse Effects

Answer 5

1. Nervous system: drowsiness, extrapyramidal symptoms’
2. Respiratory: respiratory depression
3. Cardiovascular: hypotension, ECG changes (especially QT prolongation)
4. Gastrointestinal: constipation, dry mouth

Question 6

Stemetil
Contraindications

Answer 6

KCSNPNP
1. Known hypersensitivity to phenothiazines
2. CNS depression
3. Shock from any cause or other circulatory compromise
4. Not for use in pregnancy
5. Paediatric patients <18yrs
6. Not to be given in conjunction with intravenous amiodarone
7. Previous oral prochlorperazine within last 8 hours.

Question 7

Stemetil
Precautions

Answer 7

1. Renal Dysfunction
2. Parkinson’s disease
3. Myasthenia gravis
4. Epilepsy
5. Caution in elderly - increased risk of dystonic reactions

Question 8

Stemetil
Dose

Answer 8

Adult >18
12.5mg deep IMI
Single dose only.