Magnesium Sulphate

Question 1

Magnesium Sulphate
Type

Answer 1

Electrolyte solution

Question 2

Magnesium Sulphate
Presentation

Answer 2

2.5g in 5ml (50% solution)

Question 3

Magnesium Sulphate
Actions

Answer 3

Magnesium is the second most abundant intracellular cation. Less than 1% is present in the extracellular fluid. Magnesium is involved in the processes regulating sodium and potassium movement across cell membranes and, as such, it may promote myocardial cell membrane stability.

Question 4

Magnesium Sulphate
Uses

Answer 4

Seizures due to eclampsia

ICP uses:
Torsades de pointes
Refractory VF
Symptomatic pre-eclampsia - hypertensive pregnancy pt (20-40 to 6/52 post-partum) presenting as unwell (altered LOC, headache, abdo pain, visual disturbance etc)

Question 5

Magnesium Sulphate
Adverse effects

Answer 5

Rare - more common if serum magnesium is normal
1. Respiratory depression
2. Nausea and vomiting
3. Hypotension
4. Confusion
5. Bradycardia

Question 6

Magnesium Sulphate
Contraindications

Answer 6

1. AV block
2. Renal failure
3. Hepatic failure

Question 7

Magnesium Sulphate
Precautions

Answer 7

Myasthenia gravis

Question 8

Magnesium Sulphate
Dose

Answer 8

AP dose of eclamptic seizures
2.5g IV/IO over 30-60 seconds

Question 9

Magnesium Sulphate
Special Notes

Answer 9

Prolonged hypotension post magnesium administration - if unresponsive to fluids, patient may be treated with IV calcium (call ICP for back up)