Prochlorperazine

Question 1

What is the presentation of Prochlorperazine?

Answer 1

12.5mg in 1mL

Question 2

What is the pharmacology and action of Prochlorperazine?

Answer 2

An anti-emetic.
Action:
1. Acts on several central neurotransmitter systems

Question 3

List the PEI’s for Prochlorperazine.

Answer 3

Treatment or prophylaxis of nausea/vomiting for:

1. Motion sickness
2. Planned aeromedical evacuation
3. Known allergy or C/I to Ondansetron
4. Headache irrespective of nausea/vomiting
5. Vertigo

Question 4

List the contraindications for Prochlorperazine.

Answer 4

1. Circulatory collapse (cool, pale, clammy, tachycardia, hypotension)
2. CNS depression
3. Previous hypersensitivity
4. Patients <21
5. Pregnancy

Question 5

List the precautions for Prochlorperazine.

Answer 5

1. Hypotension
2. Epilepsy
3. Pts affected by alcohol or on anti-depressants

Question 6

List the side effects for Prochlorperazine.

Answer 6

1. Drowsiness
2. Blurred vision
3. Hypotension
4. Sinus tachycardia
5. Skin rash
6. Extrapyramidal reactions (usually the dystonic type)

Question 7

List the onset, peak and duration of IM Prochlorperazine.

Answer 7

O: 20mins
P: 40mins
D: 6 hours