Fentanyl Flashcards
1
Q
What is the presentation of Fentanyl?
A
100mcg in 2mL
250mcg in 1mL (cartridge)
2
Q
Outline the pharmacology of Fentanyl, and list the 4 actions.
A
A synthetic opioid analgesic. Actions: CNS EFFECTS 1. Depression - leading to analgesia 2. Respiratory depression - leading to apnoea 3. Dependence CARDIOVASCULAR EFFECTS 4. Decreases conduction velocity via the AV node
3
Q
How is Fentanyl metabolised and excreted?
A
Metabolised by the liver.
Excreted by the kidneys.
4
Q
List the PEI’s for Fentanyl, and outline the specific indications as an analgesic option.
A
- Sedation to facilitate intubation.
- Sedation to maintain intubation.
- Sedation to facilitate transthoracic pacing.
- Sedation to facilitate synchronised cardioversion.
- CPR interfering pt (ALS)
- Analgesia
- Hx hypersensitivity/allergy to morphine
- Known renal impairment/failure
- Short duration of action desirable
- Hypotension
- Nausea/vomiting
- Severe headache
5
Q
List the contraindications to Fentanyl.
A
- Hx hypersensitivity
2. Late second stage of labour.
6
Q
List the precautions to Fentanyl.
A
REPRICK
- Elderly/frail
- Impaired hepatic function
- Respiratory depression eg. COPD
- Current asthma
- Pts on monoamine oxidase inhibitors
- Known addiction to opioids
- Rhinitis, rhinorrhoea or facial trauma (IN route only)
7
Q
List the side effects of Fentanyl.
A
- Respiratory depression
- Apnoea
- Rigidity of the diaphragm and intercostal muscles
- Bradycardia
8
Q
What are the special notes for Fentanyl?
A
- Fentanyl is a S8 and must be accountably controlled
- Respiratory depression can be reversed with Naloxone
- 100mcg Fentanyl is equivalent in analgesic activity to 10mg of Morphine
9
Q
What is the onset, peak and duration of IV Fentanyl?
A
O: Immediate
P: <5mins
D: 30-60mins
10
Q
What is the peak of IN Fentanyl?
*Onset and duration not listed.
A
P: 2mins
