Methoxyflurane Flashcards
1
Q
What is the presentation of Methoxyflurane?
A
3mL in bottle
2
Q
What is the pharmacology of Methoxyflurane?
A
Inhalational analgesic agent at low concentrations.
3
Q
How is Methoxyflurane metabolised and excreted?
A
Metabolised by the liver.
Excreted by the lungs.
4
Q
List the PEI for Methoxyflurane.
A
- Pain relief
5
Q
List the contraindications for Methoxyflurane.
A
- Pre-existing renal disease/renal impairment
- Concurrent use of tetracycline antibiotics
- Exceeding a total dose of 6mL/24hrs
- Personal or family Hx of malignant hyperthermia
- Muscular dystrophy
6
Q
List the precautions for Methoxyflurane.
A
- Must be hand-held so that it can fall away from pt face if unconsciousness occurs. Operator may assist but should monitor consciousness.
- Pre-eclampsia
- Concurrent use with oxytocin may cause hypotension
7
Q
List the side effects of Methoxyflurane.
A
- Drowsiness
- Decrease in BP and bradycardia (rare)
- Renal toxicity may occur if max. dose 6mL/24hrs exceeded
8
Q
What are the special notes for Methoxyflurane?
A
- Max initial priming dose is 3mL and will last 25mins. After this, an additional dose of 3mL may be administered.
- Analgesia commences after 8 - 10 breaths and ceases 3 - 5 minutes after being discontinued.
- Do not administer in confined space - ensure adequate ventilation.
- Malignant hyperthermia is a rare condition that can be triggered by volatile anaesthetics - ask about PHx/family PHx of rxns to inhaled anaesthetics.
- In pts with muscular dystrophy, volatile agents may precipitate life-threatening rhabdomyolysis.
9
Q
When does analgesia commence, last for and cease with Methoxyflurane?
A
Commences: after 8 - 10 breaths
Lasts 25mins
Ceases: 3 to 5 minutes after discontinuation
