Prions

Question 1

____ deposits, which are insoluble aggregates of a protein fragment high in _____ sheets are Histopathologic for Prions

Answer 1

Amyloid, Beta

Question 2

Prions typically have a _____ incubation period

Answer 2

Long

Question 3

Since prions are detected as “normal self” by the body, there’s no _____ in damaged tissue or ____ response

Answer 3

Inflammation, Immune

Question 4

CJD, Kuru, and Scrapie are all prions thought to be transmitted through ______

Answer 4

Infection

Question 5

3 Infectious prions:

Answer 5

1. CJD
2. Kuru
3. Scrapie

Question 6

Gerstmann-Straussler-Scheinker is a prion transmitted through ____

Answer 6

Inheritance

Question 7

3 Inherited Prion diseases

Answer 7

1. GSS
2. Familial Fatal insomnia (FFI)
3. Inherited CJD

Question 8

The transformation of PrP_____ into PrP_____ is thought to be key in prion disease

Answer 8

C, Sc