Gram Positive Rods Flashcards
Dr. Corbett
Corynebacteriuum Diptheriae, Bacillus anthracis, Listeria Monocytogenes, and the Clostridiums (perf, botulin, tetani, difficlie, are all examples of Gram _____ _____
Positive Rods
Of the Gram Positive rods, what do diphtheriae and Listeria have in common?
Non-spore forming
Bacillus anthracis, bacillus cereus, and the Clostridiums all form _____
spores
What does the Non-spore forming Propionbacterium Acnes share with the Spore-forming Clostridia?
They’re both Anaerobic!
Diptheria makes _____-Toxin which inactivates _____ by ADP-ribosylating it.
EF-2 (Elongation Factor)
Diptheria typically presents in throat and nasopharynx with the clinical distinction of a “bull-neck” _____ that forms
gray pseudomembrane
Tinsdale’s agar and Postassium tellurite are both used to identify the Gram positive, club-shaped bacteria known as _____
Diphtheria
What is special about Listeria’s pathogenesis?
It uses membrane-damaging-toxin and recreates actin to escape
A gram-positive bacteria with tumbling motility would make you suspect _____
Listeria
Anthrax’s 2 main toxins
- Edema Factor
2. Lethal Toxin
If you see Non-motile Endospores with Gram positive bacilli and a COMMA SHAPE, you should suspect
Anthrax
If you see air in muscle from decay, you would suspect Clostridium _____ causing Myonecrosis
Perfringens
What gram positive spore-producing bacteria produces Alpha-toxin, causes “gas gangrene” and a double zone of hemolysis?
Clostridium Perfringens
The Botulinum toxin chops the _____ proteins, not allowing Ach vesicles to dock and fuse
SNARE
Tetanus toxin blocks neurotransmitter release at _____ synapses
Inhibitory
C. diff inactivates _____ family proteins
Rho
Anthrax’s 2 main Toxins Edema Factor (EF) and Lethal Factor (LF) both bind to ________ before entering cells. Antibodies to this are protective against the toxic effects of EF and LF
Protective Antigen (PA)
What makes culturing Clostridia difficult?
They’re Anaerobic
If you give an infant honey, they risk getting ______
botulism
Botulin vs Tetanus
Botulin = Flaccid Tetanus = Spastic
Clostridium Perfingen’s Blood agar clinical Identifier?
Double Zone of Beta-Hemolysis
