Principles of Antibiotics

Question 1

Therapeutic Index:

Answer 1

Toxic Dose/ Effective Dose

Question 2

Beta-Lactamase and Aminoglycoside 3’-phosphotransferase are two examples of _____ ___

Answer 2

Resistance Genes

Question 3

_____ Therapy is employed once the infectious organism is identified

Answer 3

Definitive

Question 4

_____ Therapy covers all likely pathogens with broad-spectrum.

Answer 4

Empiric

Question 5

_____ Therapy is employed before any infection has occurred.

Answer 5

Prophylactic

Question 6

MIC vs MBC

Answer 6

• MIC is when you see inhibition in tube
• MBC is when you see inhibition on plate
• MBC often takes more

Question 7

If MIC is within therapeutic range of drug, but MBC is not, then the drug is ______

Answer 7

Bacteriostatic

Question 8

if MBC is within therapeutic range of drug, then the drug is _____

Answer 8

Bactericidal

Question 9

Cycloserine, Vancomycin, Bacitracin, Fostomycin, Penicillin, Cephalosporin, Monobactams, and Carbapenems all inhibit ____ ____

Answer 9

Cell-wall Synthesis

Question 10

Rifampin targets _____

Answer 10

RNA polymerase

Question 11

Erythromycin, Chloramphenicol, Clindamycin, Tetracycline, Spectinomycin, Streptomycin, Getamicin, Amikacin all inhibit _____ _____

Answer 11

Protein Synthesis

Question 12

Nalidixic acid and quinolones target _____ _____

Answer 12

DNA Gyrase

Question 13

Trimethoprim and Sulfonamides target _____ ____

Answer 13

Folic Acid Metabolism