Antibiotics targeting Bacterial Cell Wall

Question 1

The _____ enzyme joins bacterial sugars to make Polysaccharide chains

Answer 1

Transglycosylase

Question 2

The ____ enzymes join the sugar-linked peptides to x-link polysaccharide chains

Answer 2

Transpeptidase

Question 3

Normally, bacterial cell walls grow with the D-Ala D-ala being link by a _____ attached to an anyme, which then allows Glycine to come in with a substitution reaction

Answer 3

Serine

Question 4

B-lactam antibiotics cause the amino acid ____ to irreversibly bind onto the b-lactam ring

Answer 4

Serine

Question 5

Clavulanic acid and Tazobactam, and Avibactam are all _____ inhibitors, which is great for pharmacists to fight back!

Answer 5

B-lactamase

Question 6

N-acetyl Glucosamine and N-acetylemuramic acid are:

Answer 6

Constituents of the peptidoglycan layer

Question 7

Cefepime is a ___th generation Cephalosporin, which is most resistant to the B-lactamases and is true Broad spectrum

Answer 7

4

Question 8

Monobactam antibiotics only work toward Gram _____

Answer 8

Negative

Question 9

Daptomycin is a bacterial cell membrane ____ former, without cell rupture

Answer 9

Pore

Question 10

Polymyxins target Gram _____ bacteria

Answer 10

Negative

Question 11

For cell wall assembly, Nag needs to go to NAM; the drug _____ blocks this (GREEK LIGHT)

Answer 11

Fosfomycin

Question 12

Fosfomycin binds to the _____ enzyme to block NAG from going to NAM in Cell wall assembly

Answer 12

MurA

Question 13

For cell wall assembly, P-P needs to get phosphatased to bring NAM-NAG outside, the drug _____ blocks this

Answer 13

Bacitracin (Base Hunter makes your Pee Pee go Up)

Question 14

Bacitaricin inhibits the lipid ____ that helps become a carrier of the NAM-Nag

Answer 14

Phosphatase

Question 15

The antibiotic ______ blocks the L-ALA transformation into D-ALA D-ALA

Answer 15

D-cycloserine

Question 16

D-cycloserine blocks _____ from becoming ______

Answer 16

L-ala, D-ala

Question 17

The Best Cephalosporin for MRSA is ______, aside from 4th gens

Answer 17

Ceftaroline

Question 18

3 B-lactamase inhibitors

Answer 18

1. Clavulanic Acid
2. Tazobactam
3. Avibactam

Question 19

3rd Generation _____ such as Ceftazidime, extend Gram - at the expense of Gram + and WON’T CROSS-REACT with Penicillin allergies

Answer 19

Cephalosporins

Question 20

Two differences between Cefazolin (1st gen Cephalo) and Cefepime (4th gen Cephalo)

Answer 20

1. 4th Gen penetrates CNS

2. 4th gen works both Gram Positive and Gram Negative