Antimycobacterial Therapies

Question 1

Isoniazid, Rifampin, Pyrazinamide, and Ethambutol are all ____ line drugs to treat ____

Answer 1

First, TB

Question 2

If TB is resistant to both Isoniazid and Rifampin, you would want to consider ______ _____ drugs

Answer 2

Second Line

Question 3

Pyrazinamide, is a `1st line Anti-TB drug inhibits protein synthesis in _____ bacteria

Answer 3

Dormant

Question 4

Ethionamide, P-aminosalicyclic acid, Streptomycin, Floxacins are all examples of _____ line drugs to treat _____

Answer 4

Second, TB

Question 5

Acyl Lipids, Mycolate, Arabinogalactan, and Lipoarabinomannan are all examples of ______-bacterial specific features

Answer 5

Myco

Question 6

Isoniazid, Ehtionamide, and PAS all target _____ to treat TB

Answer 6

Mycolate

Question 7

Ethambutol is low-key racist because it targets _____ to treat TB

Answer 7

Arabinogalactan

Question 8

TB tx duration for Culture + patient?

Answer 8

8 weeks intensive + 18 weeks continuation

Question 9

TB tx duration for Culture - patient?

Answer 9

8 weeks intensive + 8 weeks continuation (10 weeks less)

Question 10

During intensive phase you use what 4 TB drugs? (preferably once daily)

Answer 10

1. INH
2. RIF
3. PZA
4. EMB

Question 11

During continuation phase, you use what 2 TB drugs?

Answer 11

1. INH

2. RIF

Question 12

INH-NAD (active Isoniazid by KatG); inhibits the _____ multi-enzyme system that lengthens fatty chains for Mycobacteria

Answer 12

FASII

Question 13

Patients taking Isoniazid should be supplemented with pyrdoxine (B6) because

Answer 13

Peripheral neuro problems

Question 14

The 1st line TB drug _____ (____) targets dormant Mycobacterium

Answer 14

Pyrazinamide (PZA)

Question 15

Ethambutol (EMB) targets both _____ and ____ arabinosyl transferases to stop Tuberculosis making cell wall

Answer 15

EmbA and EmbB

Question 16

What 2 dosing schemes should be avoided for HIV-Infected persons?

Answer 16

1. Avoid 3x Week regim

2. Never 2x week regimen

Question 17

Rifampin vs Rifabutin

Answer 17

Rifabutin is less-cross-reactive and works longer