Prion infections

Question 1

Widespread gliosis and myelin degeneration with history of measles infection

Answer 1

Subacute sclerosing panencephalitis (SSPE)

Question 2

Numerous small vacuoles are formed within the neuronal cell bodies and their processes without inflammation

Answer 2

Spongiform changes in prion diseases

Question 3

Methods for destroying prions

Answer 3

Immersion in 2N alkali for one hour then autoclaving at 132 C for one hour

Undiluted Na hypochlorite for 1 hour

Question 4

Rapidly progressive neurodegenerative disease that sets in between 60-70 yo without treatment options

Answer 4

CJD

Question 5

CJD that can occur from contamination through certain medical procedures of brain or nervous tissue

Answer 5

Transmissible-acquired-iatrogenic

Question 6

Transmission of nvCJD

Answer 6

From cows to humans from eating BSE infected meat

Question 7

Symptoms present in nvCJD and not CJD

Answer 7

Painful sensory complaints

Question 8

Presence of distinctive dense core PrP containing plaques surrounded by halo spongiform changes

Answer 8

nvCJD

Question 9

Detection in CSF is indicative of substantial, rapid neuronal destruction

Answer 9

14-3-3 proteins

Question 10

Group of highly conserved proteins composed of several isoforms that are involved in the regulation of protein phosphorylation and mitogen-activated protein kinase pathways

Answer 10

14-3-3 proteins