Drugs for neurodegenerative disorders

Question 1

CV side effects of levodopa

Answer 1

Cardiac arrhythmias
Postural hypotension

Question 2

Drug interactions of levodopa

Answer 2

Pyridoxine/Vit B6

MAO-A inhibitors

Question 3

Contraindications of levodopa

Answer 3

Psychotic pts
Angle-closure glaucoma

Question 4

Effective drug class choice in on-off phenomenon from levodopa

Answer 4

Dopaminergic agonists

Question 5

Dopaminergic agonists that act on D2 receptors only

Answer 5

Bromocriptine
Ropinirole

Question 6

Dopaminergic agonists that act on D3 receptors

Answer 6

Pramipexole
Rotigotine

Question 7

Dopaminergic agonist that acts on both D1 and D2 receptors

Answer 7

Pergolide

Question 8

GI side effect of dopaminergic agents

Answer 8

Anorexia
N/V
Reflux esophagitis
Bleeding from peptic ulcer

Question 9

CV side effects of dopaminergic agents

Answer 9

Postural hypotension
Painless digital vasospasm
Peripheral edema

Question 10

Types of MAO-B inhibitors used to treat Parkinson’s

Answer 10

Selegiline
Rasagiline

Question 11

Adjuvant therapy for pts with a declining or fluctuating response to levodopa that enhances or prolongs the effect to levodopa

Answer 11

MAO-B inhibitor

Question 12

Drug interaction of MAO-B inhibitors

Answer 12

May cause serotonin syndrome if taken with meperidine

Question 13

COMT inhibitor that acts peripherally

Answer 13

Entacapone

Question 14

COMT inhibitor that acts centrally

Answer 14

Tolcapone

Question 15

Drug class that acts by diminishing the metabolism of levodopa, thereby increasing its availability

Answer 15

COMT inhibitors

Question 16

Specific side effect to monitor with tolcapone

Answer 16

Increase in LFTs, rarely associated with acute hepatic failure

Question 17

Potent D2 dopamine agonist

Answer 17

Apomorphine

Question 18

Drug used for the temporary relief of off-periods of akinesia in pts on dopaminergic therapy

Answer 18

Apomorphine

Question 19

Specific side effect of apomorphine

Answer 19

Troublesome nausea, especially at initiation

Question 20

Antiviral agent that may potentiate dopaminergic function

Answer 20

Amantadine

Question 21

Skin side effect of amantadine

Answer 21

Livedo reticularis

Question 22

Central anticholinergics used in Parkinson’s

Answer 22

Trihexyphenidyl
Procyclidine
Biperiden

Question 23

Drug classes that improves the tremor and rigidity of parkinsonism, but has little effect on bradykinesia

Answer 23

Central anticholinergics
Antimuscarinic agent (benztropine)

Question 24

Drug that acts as antagonist at M receptors in basal ganglia

Answer 24

Benztropine

Question 25

Typical antimuscarinic effects

Answer 25

Sedation Mydriasis Urinary retention Constipation Confusion Dry mouth

Question 26

Agents that can cause drug-induced parkinsonism

Answer 26

Reserpine Tetrabenazine Haloperidol Metoclopramide MPTP

Question 27

Treatment options for non-parkinson movement disroders

Answer 27

Beta blockers Drugs potentiating GABA-a receptors in CNS

Question 28

Drugs that potentiate GABA-a receptors in CNS

Answer 28

Topiramate Primidone Benzodiazepines

Question 29

Drugs that act by depleting dopamine from nerve endings, used in Huntington's disease

Answer 29

Tetrabenazine Deutetrabenazine Reserpine

Question 30

Drugs that act as dopamine receptor blockers, used in Huntington's disease

Answer 30

Haloperidol Fluphenazine

Question 31

Drugs that block central D2 receptors, used in tic disorders

Answer 31

Pimozide Haloperidol Fluphenazine

Question 32

Alpha-2 adrenergic agonists used in Tourettes and ADHD

Answer 32

Guanfacine Clonidine

Question 33

Drug class/type used in restless leg syndrome

Answer 33

Dopamine agonists Gabapentin

Question 34

Drug classes used in treatment of Alzheimer's disease

Answer 34

Acetylcholinesterase inhibitors NMDA receptor antagonist Inhibitors of microtubule disassembly

Question 35

Types of acetylcholinesterase inhibitors, used in Alzheimer's

Answer 35

Donepezil Rivastigmine Galantamine Tacrine

Question 36

NMDA receptor antagonist

Answer 36

Memantine

Question 37

Mechanism of memantine

Answer 37

Decreases IC Ca accumulation, aiding in prevention of excitotoxic neuronal damage Inhibits glutamate excitotoxicity that damages neurons

Question 38

Inhibitor of microtubule disassembly in Alzheimer's

Answer 38

Epothilone-D

Question 39

Drug used for ALS

Answer 39

Riluzole

Question 40

Mechanism of riluzole

Answer 40

reduces presynaptic glutamate release