Principles Of Immunisation Flashcards
What are the different type of vaccines?
Toxoid
Live attenuated
Inactivated
Subunit
What are contraindications of vaccination?
Temporary and permanent
What is herd immunity?
Well vaccinated population
Reduces risk of unvaccinated individuals being exposed to infection
What makes a good vaccine?
Potent antibody response -
Challenges facing vaccines
Cannot elicit immunity against all diseases
Persistence (life long protection)
Protection of vulnerable groups
Antigenic shift/drift cold chain network
What is the cold chain network?
….. main ting product quality from time of vaccine manufacture to point of administration.
What is antigenic shift?
Antigenic shift is the process by which two or more different strains of a virus, or strains of two or more different viruses, combine to form a new subtype having a mixture of the surface antigens of the two or more original strains
What are neonates?
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What is a conjugate cancer?
?
What is the effect of vaccinations in young and old? What are the differences?
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Why should we give everyone the HPV vaccine?
?
What is immunotherapy?
used in adaptive immune system
Powerful anti-tumour responses
Antibodies that inhibit checkpoints - so that immune system can recognise tumour and destroy it.
What are the correlations between vaccines and immunotherapy?
Both- prevents tumours from returning etc
Generates much more potent vaccines
What are personalised vaccines/ vaccinomics?
….
What is the next target for complete eradication by immunisation?
Hep B (after polio has been eradicated).
Hep B- associated with liver cancer.
