Genetic Basis Of Complex Inheritance

Question 1

Contributions of genetic and environmental factors to human diseases

Answer 1

Both

Question 2

Penetrate

Answer 2

Frequency with which a trait in manifested by individuals carrying the gene.

Question 3

Cystic fibrosis

Answer 3

Common in Caucasians

Question 4

Genomic imprinting

Answer 4

Gene expression

Question 5

UDP

Answer 5

2 chromosomes from same parent (whole set from one parent)

Causes eg too many teeth
Massive placenta

Question 6

Gyogenic

Answer 6

Two maternal chromosomes

Question 7

Androgenic

Answer 7

2 paternal genomes

Question 8

Angel man syndrome and

Answer 8

Prada William syndrome

Question 9

Mitochondrial inheritance

Answer 9

From mother

If mother has mitochondrial problem - will be passed on

Question 10

Myoclonus epilepsy

Answer 10

Muscle problem with epilepsy

Question 11

Multigenic/ complex inheritance

Answer 11

Often seen in common conditions e.g:
Heart disease, breast cancer, autism

Multiple low penetrate variants

Rare high penetrate variants (schizophrenia)

Environmental factors - often significant