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Principles of disease Jess > Chemotherapy > Flashcards

Chemotherapy Flashcards

1
Q

Findings of pharmokinetics include

A

Half life,

Excretion

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2
Q

Adjuvant means?

A

Treatment improves survival

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3
Q

Neoadjuvant means?

A

May improve survival through increasing operability

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4
Q

Stages of mitosis?

A 
Interphase
Prophase
Metaphase
Anaphase
Telophase
Daguhtercells
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5
Q

What are alkylating agents?

A

Alkyl groups in chemotherapy drugs that allow bonds with other molecules

Cannot act as templates for new DNA formation

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6
Q

Modes of action of chemotherapy drugs

A

Antimetabolites

Alkylating agents

Vinca alkaloids

Taxanes

Antimitotic antibiotics

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7
Q

Principles underlying combination chemotherapy

A

Combining those with different mechanisms of action - synergistic/ additive
Reduces risk of developing resistance

Dissimilar toxicity profile - eg not both with neurotoxicity
Give each to max tolerated dose

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8
Q

Possible side-effects of chemotherapy

A 
Alopecia 
Mucositis 
Pulmonary fibrosis 
Cardiotoxicty 
Local reaction
Renal failure
Myelosuppression
Phlebitis
Neuropathy
Myalgia
Sterility
Cystitis 
Diarrhoea
Nausea/vomiting
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9
Q

Mucositis

A

Inflammation and ulcerative of mucous lining

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10
Q

Alopecia

A

Hair loss

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11
Q

Pulmonary fibrosis

A

Respiratory disease
Scars formed in lung tissues
Breathing problems

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12
Q

Cardiotoxicity

A

Damage to heart muscle

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13
Q

Renal failure

A

Kidney failure

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14
Q

Myelosurpression

A

Bone marrow activity decreased

Fewer blood cells

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15
Q

Phlebitis

A

Inflammation of vein, usually in legs

Most commonly in superficial veins. Also occurs in conjunction with thrombosis.

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16
Q

Neuropathy

A

Damage to nerves, impairing sensation, movement etc

17
Q

Myalgia

A

Muscle pain

18
Q

Sterility

A

Infertility

19
Q

Cystitis

A

Inflammation of urinary bladder, caused by infection, frequent, painful urination

20
Q

Most distressing side-effects of chemotherapy

A 
Vomiting
Nausea
Alopecia
Thought of coming fo treatment
Length of time treatment takes 
The injection
Shortness of breath
Constantly tired
Difficulty sleeping
Affects family/ partner
21
Q

Systemic therapy not chemotherapy

A

Hormonal drugs -

Targeted drugs

22
Q

Systemic cheaply for cancer is

A

Getting smarter

More specific

Personalised medicine

Molecular biology key to progress

Immunotherapy is effective but is it affordable?

Principles of disease Jess (36 decks)

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