Primary Sclerosing Cholangitis Flashcards
1
Q
What is PSC?
A
Primary sclerosing cholangitis
Chronic progressive cholestatic liver disease
2
Q
What is the pathophysiology of PSC?
A
Inflammation, fibrosis and strictures of the intra and extra hepatic bile ducts
3
Q
What conditions are associated with PSC?
A
UC
HIV
4
Q
What are risk factors for PSC?
A
Male
IBD
5
Q
What are the clinical features of PSC?
A
Cholestasis
- jaundice
- pruritus
RUQ pain
Fatigue
6
Q
What investigations are done for suspected PSC?
A
Bloods
- LFTs
- FBC
- clotting screen
AMA antibody negative
Abdominal USS
MRCP
ERCP
7
Q
What do the LFTs show in PSC?
A
Raised ALP
Raised bilirubin
Raised GGT
8
Q
How is PSC managed?
A
Colestyramine - pruritus relief
Liver transplant
9
Q
What are the complications of PSC?
A
Cholangiocarcinoma
Increased risk of colorectal cancer
