Coeliac Disease Flashcards
1
Q
What is coeliac disease?
A
Autoimmune disease that causes intolerance to gluten
2
Q
What are symptoms of coeliac?
A
Diarrhoea Bloating Flatulence Tiredness Rash
3
Q
What is the rash in coeliac?
A
Dermatitis herpetiformis
4
Q
What type of rash is dermatitis herpetiformis?
A
Itchy, vesicular rash
Clusters on extensor surfaces
5
Q
What causes dermatitis herpetiformis?
A
IgA deposition
6
Q
What gene is involved in coeliac?
A
HLA-DQ2
7
Q
What is the enzyme involved?
A
Anti-tissue transglutaminase `
8
Q
How is coeliac disease diagnosed?
A
Bloods
- FBC
- anti-tissue transglutaminase antibodies
Duodenal biopsy
9
Q
What will be visible in the biopsy?
A
Crypt atrophy
Villous atrophy
10
Q
What is a consequence of coeliac disease?
A
Iron deficiency anaemia
11
Q
Why is there anaemia?
A
Consequence due to villous atrophy
12
Q
How is coeliac disease managed?
A
Gluten free diet
