PRELIM 05 - Suppositories Flashcards
Are solid dosage forms intended for insertion into the body orfice where they melt, soften, dissolve, and exert localized and systemic effect
Suppositories
3 types of suppositories
Rectal, Urethral (Bougies), Vaginal (Pessaries)
Are cylindrical and tapered at one end; has a bullet shape (Types of suppositories)
Rectal suppository
Used for the dilation of the uterus, anti-infective, and erectile dysfunction; has a slender of pencil shape (Types of suppositories)
Urethral (Bougies) suppository
Used as an antifungal, anti-infective, and contraceptive; has a globular, oviform, and core/conical shape (Types of suppositories)
Vaginal (Pessaries) suppository
3 methods of preparation for suppositories
Molding from melt/Fusion method, Compression method, Hand rolling/Shaping method
3 classifications of suppository bases
Fatty/Oleaginous, Water-soluble/Water-miscible, Miscellaneous
Frequently/most commonly used suppository base; usually cocoa butter or theobroma oil (Classifications of suppository bases)
Fatty/Oleaginous bases
2 other triglycerides used for fatty/oleaginous bases
Wecobee bases, Witepsol bases
Are bases derived from coconut oil
Wecobee bases
Are bases derived from fatty acids C12-C18
Witepsol bases
The main members of this group are bases of glycerinated gelatin and bases of polyethylene glycols (Classifications of suppository bases)
Water-soluble/Water-miscible bases
The hygroscopic nature of this glycerin has the tendency to absorb moisture, causing it to lose shape and consistency, and lose the dehydrating effect
Glycerinated gelatin
Includes a mixture of oleaginous and water-miscible materials (Classifications of suppository bases)
Miscellaneous bases
