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PH 107.1 - Pharmaceutical Dosage Forms, Drug Delivery Systems, and Medical Devices (Lab) > PRELIM 02 - Powders > Flashcards

PRELIM 02 - Powders Flashcards

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USMLE® Step 1 flashcards
1
Q

Are intimate mixtures of drugs that is intended for internal or external use

A

Powders

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2
Q

Powders that are taken orally after mixing with water or inhaled for local effects or systemic effect

A

Internal use medicated powders

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3
Q

Powders that are dusted on the affected area from sifter-type container or applied from powder aerosol

A

External use medicated powders

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4
Q

Process of reducing the particle size of the powder to increase the solubility of the powder

A

Comminution/Particle size reduction

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5
Q

2 types of comminution

A

Large Scale, Extemporaneous/Small scale

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6
Q

Uses large mills and pulverizers (Type of comminution/particle size reduction)

A

Large scale

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7
Q

Utilizes trituration, pulverization by intervention, and levigation (Type of comminution/particle size reduction)

A

Extemporaneous/Small-scale

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8
Q

3 types of extemporaneous/small scale comminution

A

Trituration, Pulverization with intervention, Levigation

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9
Q

Grinding a drug with the use of mortar and pestle (Types of extemporaneous/small scale comminution)

A

Trituration

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10
Q

Adding of volatile substance that aid in pulverization process (Types of extemporaneous/small scale comminution)

A

Pulverization with intervention

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11
Q

Commonly used in small scale preparation of ointments to reduce the grittiness of added powders (Types of extemporaneous/small scale comminution)

A

Levigation

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12
Q

Refers to an agent that is a small amount of liquid in which the powder is insoluble; used in levigation

A

Levigating agent

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13
Q

Type of mortar that has a rough surface

A

Porcelain mortar

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14
Q

Type of mortar that has a smooth surface

A

Glass mortar

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15
Q

Process when two or more powdered substances are to be combined to form a uniform mixture

A

Blending/Mixing

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16
Q

Process of reducing the particle size of solid before mixing with other components, further processing, or incorporation into a final product

A

Mixing

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17
Q

2 types of blending/mixing

A

Large scale, Extemporaneous/Small scale

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18
Q

5 types of extemporaneous/small scale blending/mixing

A

Spatulation, Trituration, Sifting, Tumbling, Geometric dilution

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19
Q

Process of the movement of spatula on a sheet of paper/ointment tile (Types of extemporaneous/small scale blending/mixing)

A

Spatulation

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20
Q

Are mixtures that liquefy when in close and prolonged contact with one another

A

Eutetic mixtures

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21
Q

Process of comminuting and mixing powders; involves the use of mortar and pestle (Types of extemporaneous/small scale blending/mixing)

A

Trituration

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22
Q

4 kinds of mortar and pestle

A

Glass, Wedgewood, Porcelain, Metal

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23
Q

Has non-porous, smooth surface used for suspensions and ointments (Types of mortar and pestle)

A

Glass

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24
Q

Used for crystalline solids (Types of mortar and pestle)

A

Wedgewood

25
Q

Used for soft aggregates/crystalline (Types of mortar and pestle)

A

Porcelain

26
Q

Not to be used in reactive substance (Types of mortar and pestle)

A

Metal

27
Q

Process where powders are mixed by passing through sifters; results in light, fluffy product (Types of extemporaneous/small scale blending/mixing)

A

Sifting

28
Q

Process of blending powders in a rotating chamber; mixing is thorough but time consuming (Types of extemporaneous/small scale blending/mixing)

A

Tumbling

29
Q

Used when a small amount of potent substance is mixed with a large amount of diluent (Types of extemporaneous/small scale blending/mixing)

A

Geometric dilution

30
Q

Process where particles are passed by mechanical shaking through a series of sieves (Methods of determining particle size)

A

Sieving

31
Q

Process where particles are sized through the use of a calibrated grid background (Methods of determining particle size)

A

Microscopy

32
Q

Process where particle size is determined by measuring the terminal settling velocity of particles through a liquid medium in a gravitational or centrifugal environment (Methods of determining particle size)

A

Sedimentation rate

33
Q

Range used in sedimentation rate

A

0.8-300 micrometers

34
Q

Sedimentation rate is calculated using the __________

A

Stoke’s law

35
Q

Process of determining the reduction in light reaching the sensor as it passes through a sensor (Methods of determining particle size)

A

Light energy diffraction/Light scattering

36
Q

Process where purified laser is fired through an aerosolized particle spray and photographed in three dimensions with a holographic camera (Methods of determining particle size)

A

Laser holography

37
Q

Process that is driven by airstreams that will hit a surface in its path, provided that its inertia is sufficient to overcome the drag force that tends to keep in the airstreams (Methods of determining particle size)

A

Cascade impaction

38
Q

Nmt 20% thru a No. 60 sieve (USP standard for powders of animal & vegetable drugs)

A

Very coarse (No. 8 sieve)

39
Q

Nmt 40% thru a No. 60 sieve (USP standard for powders of animal & vegetable drugs)

A

Coarse (No. 20 sieve)

40
Q

Nmt 40% thru a No. 80 sieve (USP standard for powders of animal & vegetable drugs)

A

Moderately coarse (No. 40 sieve)

41
Q

Nmt 40% thru a No. 100 sieve (USP standard for powders of animal & vegetable drugs)

A

Fine (No. 60 sieve)

42
Q

No limit to greater fineness (USP standard for powders of animal & vegetable drugs)

A

Very fine (No. 80 sieve)

43
Q

2 types of powders

A

Bulk, Divided

44
Q

Are powders dispersed in bulk form (Types of powders)

A

Bulk powders

45
Q

A bulk powder that is dissolved in warm water for vaginal use

A

Douche powder

46
Q

Powders that are in divided portions and are administered in controlled dosage (Types of powders)

A

Divided powders

47
Q

Latin name for divided powders

A

Chartulae/Chartula

48
Q

3 synonyms for chartulae/chartula

A

Chart, Powder paper, Powder pockets

49
Q

Divided powders are made using __________ method

A

Block and divide method

50
Q

4 types of papers used as packaging materials

A

Simple bond paper, Vegetable parchment, Glassine, Waxed paper

51
Q

Opaque paper with no moisture-resistant properties (Types of papers used as packaging materials)

A

Simple bond paper

52
Q

Thin, semi-opaque paper with limited moisture resistance (Types of papers used as packaging materials)

A

Vegetable parchment

53
Q

Glazed transparent paper with limited moisture resistance (Types of papers used as packaging materials)

A

Glassine

54
Q

Transparent, waterproof paper (Types of papers used as packaging materials)

A

Waxed paper

55
Q

4 commercially available sizes for powder papers

A

2.75 x 3.75 in, 3 x 4.5 in, 3.75 x 5 in, 4.5 x 6 in

56
Q

Divided powders can be prepared by __________ and __________

A

Individual weighing, Block and divide method

57
Q

Involves weighing separately before enfolding in a paper using a digital analytical balance (Methods of preparing divided powders)

A

Individual weighing

58
Q

Involved placing the prepared powder on a flat surface, forming a rectangular block of paper, and cutting the divided portions lengthwise and crosswise (Methods of preparing divided powders)

A

Block and divide method

PH 107.1 - Pharmaceutical Dosage Forms, Drug Delivery Systems, and Medical Devices (Lab) (27 decks)

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