PRELIM 04 - Capsules

Question 1

Solid dosage form in which medicinal agents and/or inert substances are enclosed within a small shell of gelatin

Answer 1

Capsules

Question 2

Obtained by partial hydrolysis of collagen from the skin, connective tissue, and bones of animals

Answer 2

Gelatin

Question 3

2 kinds of gelatin

Answer 3

Gelatin A, Gelatin B

Question 4

Obtained from acid hydrolysis (Types of gelatin)

Answer 4

Gelatin A

Question 5

Obtained from basic hydrolysis (Types of gelatin)

Answer 5

Gelatin B

Question 6

2 types of capsules

Answer 6

Hard gelatin capsule (HGC), Soft gelatin capsule (SGC)

Question 7

Contains 13-16% water; available in a variety of capsule sizes numbered from 000 (largest) to 5 (smallest) (Types of capsules)

Answer 7

Hard gelatin capsule (HGC)

Question 8

2 pieces of a hard gelatin capsule

Answer 8

Body, Cap

Question 9

3 methods of filling hard gelatin capsules

Answer 9

Punch method, Rolling method, Capsule filling machines

Question 10

Empty capsule body is held and punched vertically into the powder cake repeatedly until filled (Methods of filling hard gelatin capsules)

Answer 10

Punch method

Question 11

Using the spatula, fill the capsule by drawing the powder to the capsule body until completely filled (Methods of filling hard gelatin capsules)

Answer 11

Rolling method

Question 12

Are excipients added to fill the capsule

Answer 12

Diluents

Question 13

Example of diluent

Answer 13

Lactose

Question 14

Are excipients added to facilitate the flow of the powder

Answer 14

Lubricant

Question 15

Example of lubricant

Answer 15

Mg stearate

Question 16

Are excipients added to enhance drug dissolution

Answer 16

Wetting agent

Question 17

Example of wetting agent

Answer 17

Li2CO3

Question 18

Are prepared from gelatin shells, glycerin, sorbitol, and preservatives (Types of capsules)

Answer 18

Soft gelatin capsule

Question 19

4 methods in the preparation of soft gelatin capsule

Answer 19

Plate process, Rotary die process, Reciprocating die process, Capsule machine

Question 20

1 grain = __________ (Avoirdupois system)

Answer 20

64.8 mg

Question 21

000 (Capsule sizes)

Answer 21

15 grains

Question 22

00 (Capsule sizes)

Answer 22

10 grains

Question 23

0 (Capsule sizes)

Answer 23

7.5 grains

Question 24

1 (Capsule sizes)

Answer 24

5 grains

Question 25

2 (Capsule sizes)

Answer 25

4 grains

Question 26

3 (Capsule sizes)

Answer 26

3 grains

Question 27

4 (Capsule sizes)

Answer 27

2 grains

Question 28

5 (Capsule sizes)

Answer 28

1 grain