FINAL 05 - Emulsions (Mineral Oil Emulsion) Flashcards
A 2 phase system in which one liquid is dispersed in the form of small globules throughout another liquid in which it is immiscible
Emulsion
3 components of emulsions (IEE)
Internal phase, External phase, Emulsifying agent
Emulsion diluted with water/aqueous preparation
O/W emulsion
Emulsion diluted with oleaginous/oil miscible liquid
W/O emulsion
Phase that contains water-soluble drugs, preservatives, coloring, and flavoring agents
Aqueous phase
Phase that contains fixed/volatile drugs (oil, oil-soluble vitamins, and antiseptic)
Oil phase
Added to prevent auto-oxidation of the oil and rancidity or destruction of any vitamin resent
Antioxidant
Includes carbohydrates and gelatins; produce O/W emulsions (Types of emulsifying agents)
Natural emulsifying agents
Examples include stearyl alcohol, cetyl alcohol, and glyceryl monostearate; produce O/W emulsions (Types of emulsifying agents)
High molecular weight alcohols
__________ is employed in externally used emulsion; produce W/O emulsions
Cholesterol
Includes colloidal clays such as bentonite, magnesium hydroxide, and aluminum hydroxide; produce O/W emulsions (Types of emulsifying agents)
Finely divided solids
May be anionic, cationic, or nonionic (Types of emulsifying agents)
Synthetic (Wetting agents)
Includes triethanolamine oleate and sodium lauryl sulfate (Types of synthetic emulsifying agents)
Anionic
Includes benzalkonium chloride (Types of synthetic emulsifying agents)
Cationic
Includes lecithin (Types of synthetic emulsifying agents)
Amphoteric
Includes sorbitan esters, polyethylene glycol 400 monostearate, and polyoxyethylene sorbitan esters (Types of synthetic emulsifying agents)
Nonionic
May be O/W or W/O (Types of emulsions)
Simple
May be O/W/O or W/O/W (Types of emulsions)
Multiple
Most stable emulsion; the dispersed phase is in very small globules (Types of emulsions)
Microemulsion
Emulsifying agent and water is added first, then oil (Methods of emulsion preparation)
English/Wet method
Emulsifying agent and oil is added first, then water (Methods of emulsion preparation)
Continental/Dry method
Shaking vigorously (Methods of emulsion preparation)
Forbes/Bottle method
Hand homogenizer (Methods of emulsion preparation)
Auxiliary method
Calcium soap and soft soap (Methods of emulsion preparation)
Nascent/In situ soap method