PRELAB 3.8 QUATERNARY STRUCTURE

Question 1

It is composed of 2 or more polypeptides in _________

Answer 1

tertiary structure

Question 2

What is quaternary structure of protein

Answer 2

interaction between multiple polypeptides that make up the functional protein

Question 3

It has multiple

Answer 3

polypeptide heads, or protein chains/subunits

Question 4

Each subunit in a quaternary structure contains
1)
2)
3)

Answer 4

1) Primary structure: AA seq
2) Secondary structure: AH or BPS
3) Tertiary structure: coils and planar

Question 5

The subunits are held together by
1)
2)

Answer 5

Hydrogen binding
Van Der Waals forces- for nonpolar side chains

Question 6

Example of quaternary structure in the human body

Answer 6

Hemoglobin

Question 7

Hemoglobing has _____ polypetides subunits with

Answer 7

4 pp subunits: 2 alpha, 2 beta subunits

Question 8

Each subunits contains _____ where _____ is bound

Answer 8

contains iron where oxygen is bound

Question 9

One hemoglobin can transfer ______ mol at a time

Answer 9

4 oxygen molecules

Question 10

what is a domain

Answer 10

formed when PP chains with more than 200 residues fold into two or more globular clusters (domains)

Question 11

Domain is the ____ and ____ of a protein

Answer 11

functional and 3-Dimensional structure of a protein

Question 12

Many domains are _______ units tha have a characteristic of _________

Answer 12

structurally independent
small globular proteins

Question 13

Example of a domain

Answer 13

glyceraldehyde-3-phosphate dehydrogenase/GAPDH- enzyme in the production of energy and photosynthesis

Question 14

G3P is involved in________ and ______ in plants

Answer 14

glycolysis and food production in plants

Question 15

G3P has ____ domains

___ and ______ each has ____ residues causing them to have a globular shape

Answer 15

Green-colored and red-colored each has 200 residues

Question 16

The final shape is determined by the variety of bonding interactions between _____ on the AA which can be: (5)

Answer 16

side chains:
Hydrogen bonds
Salt bridges
Ionic bonds
Disulfide bonds
Hydrophobic interactions

Question 17

The critical determinant of the tertiary structure is the ___ of the amino acid side chains

Answer 17

localization

Question 18

when the AA side chain is hydrophobic the interaction is in the _______ of the tertiary structure

in hydrophilic amino acids they are positioned on the ______ where they can interact with ________

Answer 18

hydrophobic: inner structure
hydrophilic: periphery to interact with polar substances

Question 19

Quaternary structure is the interactions between different pp with ______ pp

Answer 19

more than one

Question 20

the subunits are held together by

Answer 20

non-covalent interactions

Question 21

Hemoglobin has the subunit composition _____

Answer 21

a2b2

Question 22

The ____ of 20 different AA can lead to variation in the ____ of the folded proteins

Answer 22

distinct chemical characteristics of 20 AA

3D conformation of the folded proteins

Question 23

The _____, ____, and ___ of proteins are suited to the variety of tasks for the normal function of cell

Answer 23

position, structure, and function

Question 24

One must know the properties of proteins such as (3)

Answer 24

groupings, charges, polarity

Question 25

The ____ and ___ of these side chains play an important role in predicting the ____ form of protein structure.

Answer 25

orientation and localization