PRELAB 3.8 QUATERNARY STRUCTURE Flashcards
It is composed of 2 or more polypeptides in _________
tertiary structure
What is quaternary structure of protein
interaction between multiple polypeptides that make up the functional protein
It has multiple
polypeptide heads, or protein chains/subunits
Each subunit in a quaternary structure contains
1)
2)
3)
1) Primary structure: AA seq
2) Secondary structure: AH or BPS
3) Tertiary structure: coils and planar
The subunits are held together by
1)
2)
Hydrogen binding
Van Der Waals forces- for nonpolar side chains
Example of quaternary structure in the human body
Hemoglobin
Hemoglobing has _____ polypetides subunits with
4 pp subunits: 2 alpha, 2 beta subunits
Each subunits contains _____ where _____ is bound
contains iron where oxygen is bound
One hemoglobin can transfer ______ mol at a time
4 oxygen molecules
____ is formed when PP chains with more than _______residues fold into two or more _______ clusters
domain
200
globular
Domain is the ____ and ____ of a protein
functional and 3-Dimensional structure of a protein
Many domains are _______ units tha have a characteristic of _________
structurally independent
small globular proteins
Example of a domain
glyceraldehyde-3-phosphate dehydrogenase/GAPDH- enzyme in the production of energy and photosynthesis
G3P is involved in________ and ______ in plants
glycolysis and food production in plants
G3P has ____ domains
___ and ______ each has ____ residues causing them to have a globular shape
2 domains
Green-colored and red-colored each has 200 residues
The final shape is determined by the variety of bonding interactions between _____ on the AA which can be: (5)
side chains:
Hydrogen bonds
Salt bridges
Ionic bonds
Disulfide bonds
Hydrophobic interactions
The critical determinant of the tertiary structure is the ___ of the amino acid side chains
localization
when the AA side chain is hydrophobic the interaction is in the _______ of the tertiary structure
in hydrophilic amino acids they are positioned on the ______ where they can interact with ________
hydrophobic: inner structure
hydrophilic: periphery to interact with polar substances
Quaternary structure is the interactions between different pp with ______ pp
more than one
the subunits are held together by
non-covalent interactions
Hemoglobin has the subunit composition _____
a2b2
The ____ of 20 different AA can lead to variation in the ____ of the folded proteins
distinct chemical characteristics of 20 AA
3D conformation of the folded proteins
The _____, ____, and ___ of proteins are suited to the variety of tasks for the normal function of cell
position, structure, and function
One must know the properties of proteins such as (3)
groupings, charges, polarity
The ____ and ___ of these side chains play an important role in predicting the highest form of protein structure.
orientation and localization
