Pregnancy HY Flashcards
Endometrial glands invades myometrium.
Symmetrical, soft large (globular), boggy uterus.
± Myometrial thickening on u/s
Dx/Tx & Definitive Tx?
Adenomyosis
Mirena IUD
(levonorgestrel-releasing intrauterine device)
Definitive tx: Hysterectomy
Irregularly enlarged uterus
Well-circumscribed masses in the myometrium on u/s
Dx?
Uterine leiomyoma - Fibroma
(Elevated risk of spontaneous abortion)
1 hour Oral Glucose Tolerance test done at
24w visit
(if abnormal do 3hr test)
When 1st dose of Rhogam if pt is Rh (–) & no antibodies
28w
when do all pregnant women get the Tdap vaccine?
Other recommended vaccines in pregnancy?
T-Dap (27w–)
HepB (if non-immune)
Flu vaccine (non-live)
1st Prenatal Visit (~10w) screening (5):
HIV, HBVsAg, Syphillis
UA/Ucx (Asymptomatic Bacteuria- test of cure)
Rh Status check (Indirect Coombs if blood type is Neg)
Anal Vaginal GBS swab indicated when
35-37w
(if premature labor, do it at that time)
Pre-Term Labor <32w
what is given
Magnesium
Betamethasone
Ampicillin/Amoxicillin
± Indomethacin (tocolytic)
Pre-Term Labor <34w
what is given
2 doses Betamethasone
Ampicillin/Amoxicillin
± Nifedipine (tocolytic )
Premature rupture of Membrane <34w
Mom or Fetus have compromise (like infection, bleed, etc)
NBSIM
Immediate Delivery
(Mg if <32w +Betamethasone + Ampicillin/Amoxicillin)
Premature Rupture of Membrane <34w
Mom & Fetus have no infection, bleeding, or distress
NBSIM?
Betamethasone
Ampicillin/Amoxicillin
Fetal Monitoring
Expectant management
<32w Magnesium
3 days post-partum what care does the mother receive?
2nd RhoGam dose (if no Abs)
(Baby should get 1st HBV vaccine and Vit K)
at 10w visit if mom is Rh (–) NBSIM?
NBSIM: If results (–) or (+)?
Indirect Coombs test
(check for ABs)
Negative ABs → RhoGAM at 28w (& again 3d PP)
Positive ABs → Check Father’s Rh status
FYI (out of test’s scope)
if father Rh + baby will need Doppler u/s of MCA for anemia
Polyhydraminos happens when baby pees a lot
or isn’t swallowing/drinking enough.
Causes (4)?
Twins
Diabetic Mother
Anencephaly (can’t swallow)
obstruction to swallowing (esophageal/intestinal atresias)
Oligohydraminos happens when baby can’t pee.
List 3 causes & feared complication?
Renal Agenesis
Urinary Obstruction (PUV/VUR)
Mom used ACE-I/ARBs (teratogens)
Urinary tract anomaly→olygohydraminos→Fetal Compression→ Potter Sequence:
Lung Hypoplasia/NRDS, Limb deformities, Face deformities
2 mcc of new born seizures:
Hypoglycemia → Diabetic mom, Beckwith Wiedemann
Hypocalcemia → Digeorge syndrome
Belly Size and Baby Age size discrepancy
NBSIM? Interpret outcome.
NST (Non-invasive Stress Test)
──
Reactive= 2 acceleration in 20 minutes → GOOD
Non-Reactive= get a BPP (or try waking baby up)
Non-Reactive Stress Test
NBSIM? Interpret Outcome.
Biophysical Profile (BPP)
──
Sore 0-2 = C-section now
Score 4,6 = Contraction Stress Test
──
(BPP Score will be given on test!!!)
(CST Results out of scope)
11 weeks gestation (< 20w)
Hyperemesis gravidarum
HTN
Heavy vaginal bleeding
Huge Size >Date discrepancy
± theca lutein cysts
Note: The NBME may mention these as speculum blue lesions indicating vaginal mets.
Dx?
Gestational trophoblastic Dz
(MolarPregnancy)
Theca lutein Cystic mass causing size discrepancy
30F at 35 weeks
2 day (ACUTE) history of N/V
RUQ Abd Pain + Jaundice
Hypoglycemia
Leukocytosis, Normal/↓PLTs
↑PT/PTT/Fibrin degradation
↑ ↑ AST/ALT ± ↑ GGT
Indirect Bilirubin > direct Bilirubin
↑ Creatinine
Dx/TX?
Acute fatty liver of pregnancy
(DIC like picture)
Tx: immediate delivery
30F at 35 weeks
2 week (chronic) history of Itchiness
RUQ Abd Pain/ Jaundice
Leukocytosis, Normal PLTs
↑ Total serum bile acid
↑ /nl Bilirubin
↑ AST/ALT
Dx/Tx?
Intrahepatic Cholestasis of Pregnancy
Tx: Ursodeoxycholic acid + Deliver at 36w
(or immediately if 37w)
Pre-eclampsia/Eclampsia patient with MAHA (schistocytes) with HTN, Anemia & low PLTs
↑AST/ALT
Evidence of hemolysis
(↑LDH, ↓ Haptoglobin, ↑Indirect Bilirubin)
Dx/Tx?
HELLP syndrome
Immediately Deliver
+ Magnesium (mom) + Hydralazine (for HTN)
─
Hemolysis (↓ Hb/Haptoglobin, ↑ LDH, ↑ Indirect Bili)
Elevated Liver enzymes (↑ AST/ALT)
Low Platelets
How to differentiate between HELLP syndrome and Acute Fatty Liver of Pregnancy?
AFLP → has hypoglycemia &↑ PT/PTT/ fibrin degradation product. (DIC like)
HELLP → Normal PT & PTT (no fibrin degradation)
(classic presentation)
Severe SOB, cough, hemoptysis, and weight-loss 3 weeks after an abortion.
Dx?
Choriocarcinoma
Hematogenous spread loves to go to the lungs!
MC kind of vaginal malignancy:
BRF for primary vaginal carcinoma:
Treatment/Cx:
vaginal malignancy → Squamous cell cancer
BRF → HPV 16/18/30s
Tx: Surgery & Radiation (adhesions/ vaginal stenosis)
Glandular cell vaginal malignancy.
Dx?
Clear Cell Adenocarcinoma of the Vagina
(fetus exposed to DES = T-shaped uterus)
B-HCG cutoff to see a gestational sac on an ultrasound.
bHCG > ____
> 2000
Pap-smear guidelines for pts after a Hysterectomy
(s/t endometrial hyperplasia/cancer)
Keep doing pap-smears of vaginal cuff
(only stop if hysterectomy was s/t benign reasons)
4ft tall female with amenorrhea.
Dx?
Classify the hypogonadism
Turner’s Syndrome
Hypergonadotropic Hypogonadism
Hypergonadotropic (↑ FSH/LH & ↑ GnRH)
Hypogonadism (↓ Estrogen) s/t streak ovaries
18F with Tanner 5 breasts & pubic hair with Amenorrhea
No uterus.
Dx?
Mullein agenesis (MRKH syndrome)
Breast present = Estrogen is okay
Pubic hair present = Testosterone/Progesterone is okay
Supermodel having a BMI of 17 with amenorrhea.
Classify the hypogonadism?
GnRH FSH LH E2 levels?
Hypogonadotropic Hypogonadism
HPG axis shut down= ↓ FSH/LH, ↓ GnRH (gonadotropins) & ↓ Estrogen (gonads)
1º Amenorrhea with severe lower abdominal pain at the end of the month. Bulge in vaginal vault on exam.
Dx?
Imperforate hymen
Transverse vaginal septum (rare, 2nd option)
Tx: Surgery
Treatment for Primary Dysmennorhea?
PE is normal
1st line: NSAIDs
2nd line: OCPs
s/t prostaglandins causing violent uterine contraction
25F Infertile w/Painful menses, painful poop, painful sex.
Dx/BRF/Temporary & Definitive Tx?
Endometriosis
(+) Family history
Temporary Tx: OCPs
Definitive Tx: Hysterectomy
Patho: Endometrial glands/stroma are outside the endometrium (mc in the ovaries chocolate cysts)
In Endometriosis
where is one common attachment point affected?
how is it definitively diagnosed & treated?
Can attach to utero-sacral Ligament (HY)
Definitive dx → Laparoscopy
Definitive tx → Hysterectomy
Heavy menstrual bleeding, symmetrically soft/tender uterus on bimanual exam.
Dx:
Tx:
Definitive dx:
Definitive tx:
Adenomyosis
Tx: Mirena IUD
Definitive tx: Hysterectomy
Definitive dx: Laparoscopy
(endometrial glands in myometrium)
Most effective emergency contraception.
Copper IUD
What kind of contraception should be avoided in a postpartum female?
Estrogen containing contraception
Contraception with the need for Vit D/Ca supplementation.
Depo-Provera
Reversible decr in bone mineral density
Delayed Return to fertility
(progestin injectable q3m)
23F abdominal pain, vaginal bleeding + Positive B-HCG
Dx/Tx?
Ectopic Pregnancy
Tx: Methotrexate
MTX contraindications
(2)
bHCG > 5000
Fetal cardiac activity present
If pregnancy is viable bHCG should
DOUBLE every 48hrs
PCOS patient desiring pregnancy.
Clomiphene
Letrazole
(Letrazole inhibits aromatase thus lowers E2)
PCOS criteria?
Must meet 2 for dx
Treatment of PCOS?
- Hyperandrogenism
- Irregular menses (Anovulation)
- Polycyctic ovaries on U/S
Tx: Weight-loss + OCPs
Mucopurulent vaginal discharge &
Lower Abdominal/ Adnexal tenderness
Dx/Tx?
Now has RUQ pain → dx?
Pelvic inflammatory Disease
CTX + Doxycycline (or Azithromycin)
RUQ pain → spread to liver capsule (Fitz Hugh Curtis Syndrome)
19F persents with AMS, Sudden high fevers, Red skin, + palmar exfoliating rash; recent h/o menses
Dx?
Toxic Shock Syndrome
(fyi emperic abx → Vanco + Clindamycin)
30F presents with Fever & Unilateral swelling/fluctuant mass in inferior labia.
Dx/Tx?
Bartholin Gland Abscess
Incise & Drain + WORD catheter
(for drainage & ↓recurrence)
Increased UTI risk in pregnant women s/t
High Progestin
(relaxes smooth muscle in ureters →urinary stasis)
NBSIM of Asymptomatic bacteriuria in a pregnant pt?
Amoxicillin
Cephalexin
or
Nitrofurantoin
→ Get urine Cx as TEST of CURE
Severe nausea, vomiting, and weight loss in a 23 yo F at 11 weeks gestation.
Dx/Tx?
If admitted, what is the tx?
Hyperemesis Gravidarum
Doxylamine + Vit. B6
Inpatient tx→ N Saline + Thiamine + Odansetron
Causes of increased MSAFP (2)
Incorrect Dating
Neural Tube Defects
NBSIM if pt has ↑Maternal AFP?
NBSIM if pt has (+) cell Free DNA?
For both 1st get an Ultrasound
→Amniocentesis, After u/s
NRST with a normal FHR but no accels and the child is not moving.
What is your NBSIM?
Vibro-acustic stimulation
(fetus is sleeeping)
Teratogenic drugs causing fetal:
Renal Anomalies/failure:
Ashen gray newborn + cardio collapse:
R sided heart/Tricuspid valve problems:
Poor Bone development:
Limb hypoplasia:
Intracranial hemorrhage + IUGR:
Aminoglycosides → Ototoxicity
Valproate → neural tube/spine defects
Phenytoin → cleft palate, phalanx/fingernail hypoplasia
Renal failure: ACE/ARBs
Ashen gray newborn: Chloramphenicol
R sided heart problems: Lithium
Bone development: Tetracycline
Limb hypoplasia: Thalidomide
ICH + IUGR: Warfarin
BRF for preterm labor.
Prior h/o Pre-term labor
Ultra HY
Obstetric complication associated with:
Bacterial vaginosis
Asymptomatic bacteriuria
Ureaplasma infection
Pre-Term Labor
Pre-Term Delivery
Woman with Recurrent 2nd trimester (13-24w) pregnancy losses
Dx/ Risk Factor/ Emergent Tx/ Ppx?
Cervical incompetence
H/o Conization or LEEP
Emergent tx: Cervical Cerclage
Ppx: Vaginal Progestin Suppositories
––––
memory device: second trimester = cervical cerclage
Pregnant pt with h/o Eclampsia
NBSIM?
Start Aspirin
(stop at 32w)
Preventive measure to reduce risk of neonatal/fetal infection in women with prolonged rupture of membranes:
↓ # of digital vaginal exams
- NBSIM of prolonged rupture of membranes at >37 weeks (full term)?
- NBSIM if prolonged rupture of membranes > 18 hrs?
- give Oxytocin
- give Ampicillin or Amoxicillin (for GBS ppx)
Criteria for prophylactic C section in an Infant of DM?
if estimated fetal weight is > 4,500g
> 9.15 lbs
Gestational HTN is diagnosed after ___
and at what BP?
≥ 20 weeks
140/90
Pre-Eclampsia
vs
Eclampsia
Preeclampsia = gestational HTN + Proteinuria
Eclampsia = gestational HTN + Proteinuria + Seizure
Management of Eclamptic Seizure (2)?
IV Magnesium
Immediate Delivery (after seizure is done)
Antihypertensives in pregnancy (4)
(Hypertensive moms love nifedipine)
Hydralazine
Methyl-dopa
Labetalol
Nifedipine
34F with AMS and decreased DTRs being treated for pre-eclampsia.
Dx/Tx?
Hypermagnesemia (toxicity)
CALCIUM GLUCONATE
( & stop Mg)
Gestational DM pathophysiology s/t ____ that causes insulin resistance
Human Placental Lactogen
(placental hormone)
Drug of choice for tx of Gestational DM?
Insulin
2nd line: METFORMIN
3rd line: Glyburide (Sulfonylurea)
Newborn with Respiratory Distress born to mom with gestational diabetes. Explain Pathophysiology?
Low Surfactant
(Baby has a lot of insulin suppresses surfactant synthesis)
Newborn with Small Brain (microcephaly) + Sensory Neural Hearing Loss + Periventricular Calcifications
Dx?
CMV
Newborn with Macrocephaly (Hydrocephalus) + Chorioretinitis (eye-problems) + diffuse Intracranial Calcifications
Dx?
Toxoplasmosis
pt w/ hx of Herpes
NBSIM:
If visible genital lesions during Labor?
If no visible genital lesions?
(+) Lesions = C-Section
No lesions = Vaginal delivery
NBSIM if Hep BSAg (+) mom is delivering a newborn?
Give baby:
HepB vaccine + HepB Ig
(active and passive immunity)
Biggest NBME RF for fetal tachycardia?
Maternal Fever
(Nl: 110-160)
Baby’s anterior shoulder is stuck during delivery (Dystocia).
NBSIM?
- Apply Suprapubic pressure
- If that doesn’t work do McRoberts Maneuver
Put woman knee to chest position & apply suprapubic pressure
Pregnant pt with High Fever + Fetal HR 190
Uterine tenderness, foul smelling vaginal d/c on exam
Dx/Tx/NBSIM?
Chorioamnionitis
Tx: Amp-Gentamicin
Immediate Delivery
Preterm labor management <37w
Uncomplicated
NBSIM?
Betamethasone
Ampicillin/Amoxicillin (<35w or GBS unk/+)
MCC of postpartum hemorrhage & treatment
Uterine Atony
Oxytocin
3 days postpartum + uterine tenderness.
Dx/Tx/BRF?
Endometritis
Clindamycin + Gentamicin
BRF → C-Section
(gently clean the uterus)
When do you admit pt with Post Partum Depression (2)?
-
PP Psychosis
(hearing voices, Seeing things; delusions) -
Physical evidence of suicide or infanticide
(bought a gun, Harmed baby on purpose)
Work up for pulmonary embolism in pregnant women?
First dx test:
2nd dx test if 1st normal →
3rd dx test if 2nd test low risk →
- Ultrasound compression (+DVT → Heparin)
- V/Q scan (high probability → Heparin)
- Low probability → CT Angiography chest
Algorithm on NBMEs for determining the cause of 3rd trimester (≥27w) vaginal bleeding.
1st Ask yourself → Painful or Painless
2nd Ask yourself → FHRT normal or abnormal
3rd Ask yourself → drugs, trauma or C-section?
Painless
1. vasa previa (Fetal HRT abnormalities present)
2. placenta previa (No Fetal HRT abnormalities)
Painful
1. Placental abruption (cocaine or trauma)
2. Uterine Rupture (h/o C-section → Loss of fetal station or palpable fetal parts in abdomen)
*loss of station = # becoming more +
*fetal parts are felt as bumps on abdomen or uneven abdomen)
Contraindicated exams with vasa/placenta previa.
What mode of evaluation is okay?
Digital Vaginal Exam
Speculum Exam
—-
Transvaginal ultrasound
—-
Vasa Previa → C-section
Placenta Previa → C-section if low lying
Mgt of placenta previa in unstable mom in active labor + FHRT abnormalities
versus
Mgt of placenta previa in an asymptomatic mom not in labor
Unstable → C-section immediately
Stable → Pelvic Rest (no sex) /Supportive care
Management of vasa previa & uterine rupture
C-section
(immediate)
31F at 29 weeks gestation presents with a 3 hr history of painful contractions that occur every 3-4 mins.
Consistent Contractions occurring at <37w is Pre-Term labor
Tocolysis for pts >32w
Tocolysis for pts <32w
2 protective medications:
Antibiotic:
Tocolysis >32w → Nifedipine
Tocolysis <32w → Indomethacin
Protective medications
<32w: Magnesium (neuroprotective)
<34w: Betamethasone
Antibiotic: → Amoxicillin or Ampicillin
(GBS ppx for anyone in pre-term labor)
1hr Glucose Tolerance test for GDM screening is recommended between what weeks?
24–28w
pt is 17w pregnant and has abnormal Quad Screen Results. NBSIM?
Amniocentesis for Karyotype Analysis
(only if 15-18w)
Pregnant pt with hx of 3rd Trimester IUFD.
NBSIM?
Obtain NST in 3rd Trimester
Syndrome that presents with pheochromocytomas or medullary thyroid cancer
MEN 2A & 2B
____ is generally the first manifestation of MEN 2A
medullary thyroid carcinoma
(Hypocalcemia)
FMH of neuroendocrine tumors
↑ Calcitonin
↓ Calcium
Dx?
Medullary Thyroid Carcinoma
(Men 2A >2B)
27M h/o Ulcerative Colitis (on infliximab) presents with severe bloody diarrhea, LLQ abdominal pain, and malaise.
Colonoscopy: erythematous mucosa & superficial ulcers continuously from rectum to proximal descending colon. Biopsy: Intracellular inclusion bodies.
Dx/Tx?
CMV Colitis
Ganciclovir
Excessive vomiting causes metabolic _____
Excessive Diarrhea causes metabolic ____
vomiting = Hypokalemic, Hypochloremic metabolic alkalosis
Diarrhea = Hyperchloremic metabolic acidosis (non-anion gap)
Female s/p abortion or miscarriage presents with rising bHCG levels
(± levels were initially decreasing)
Dx/Tx?
Gestational Trophoblastic dz (neoplasia)
Tx: Resection + Chemo
vs Choriocarcinoma → presents with hemoptysis ± multiple theca cysts.
Monitor hCG for 1 year ± Hysterectomy
FYI: new-onset HTN, proteinuria, or end-organ dysfunction at < 20 weeks gestation suggests GTDz
Fever + diffuse maculopapular rash in hands and feet.
Dx/Tx?
2º Syphilis
Penicillin
Baby’s born to mom’s with SLE or Sjogrens at risk for what defect?
Complete AV Block
Gestational hypertension
Pregnancy-induced hypertension (SBP ≥ 140 or DBP ≥ 90)
w/o proteinuria or end-organ dysfunction
Diagnosed at ____ weeks
≥ 20 weeks
Preeclampsia
Gestational HTN (≥20w) + ____ or ____.
Eclampsia
Gestational HTN (≥20w) + new-onset seizures
end-organ dysfunction (i.e. lab abnormalities: LFTs etc)
proteinuria
─
Occurrence of new-onset HTN, proteinuria, or end-organ dysfunction at < 20 weeks gestation is suggestive of gestational trophoblastic disease.
Fetal heart Rate Tracings Mnemonic
VEAL CHOP
Variable decels → Cord compression
Early decels → Head compression
Accelerations → Okay
Late decels → Placental insufficiency/ischemia
Fetal lung maturity by amniocentesis
→ Check ___:___ ratio
Mature if > ___:___
Lecithin to Sphingomyelin
>2:1
Contraindications to
Estrogen HRT
E2 Contraceptives
(6)
≥35 F who actively smokes
Severe HTN
h/o VTE dz → DVT, PE, Stroke, MI
h/o Breast Cancer
h/o Migraines with Auras
Hepatic Adenoma
Symmetric IUGR causes (3)
(small Head & Body)
TORCH infections
Chromosomal Abnormality
Small/Skinny mother
Asymmetric IUGR causes (4)
(normal Head + small Body)
HTN
Diabetes
SLE/APLS
Pre-Eclampsia
(s/t placental insufficiency or anomalies)
Fundal height from pubic symphysis to belly button =
___ weeks EGA
30 weeks
Order of reproductive development in girls:
TAM
Thelarchy (boobs 8 yo) → Adrenarche (Pubes 9 yo) →
Menarchy (10 yo)
Contraception associated with delayed return of fertility.
Depo-Provera
The 3 polymicrobial OBGYN infections:
Bartholin Gland Abscess
Endometritis
Chorioamnionitis
Female + breast mass just below the nipple.
Is breast feeding or was breast feeding.
END of STORY → Dx?
Classic location?
Galactocele
Subareolar mass
Breast mass with recent breast trauma:
dx/tx?
Fat Necrosis
no tx
Woman on OCPs gets pregnant while on
* st. John’s Wort
* griseofulvin (Tinea)
*carbamazepine (seizures, Trigeminal neuralgia, BPD)
*phenytoin (seizures)
* barbiturates
*rifampin
Why is that?
Cyp-P450 inducers
↑ enzymes that break down OCPs
so OCPs don’t work
Lynch syndrome (AD)
aka Hereditary nonpolyposis colon cancer (HNPCC)
Affected pts develop a few small adenomas that rapidly progress to colorectal cancer at an early age.
Also at ↑ risk of _____ cancer (4)
Individuals are asymptomatic until they present with symptoms of advanced cancer.
Mutation in ______ gene.
Gastric, Endometrial, Colon, and Ovarian cancers
(GECkO)
DNA mismatch repair (MMR) gene
Arrest of Labor (no cervical changes)
Protraction of Labor (inadequate rate of cervical change)
Management for both
Are contractions adequate (q2-3m + MVU>200)?
Yes → C-section
No → Oxytocin → C-section (if, oxy doesn’t work)
Contractions are adequate, if both are true.
Contractions every ___ min
MVU > ___
—-
Calculating MVU
every 2-3 min
MVU >200
—-
(Amplitude of contraction) x (# of contractions in 10 min)
Example: 2 minutes = 1 contraction of 60mmHg
2 min x 5 = 10 min
60mmHg x 5 = 300 MVU → Adequate
Respiratory distress in newborns
Preterm → NRDS
tx(2)/cx (3)
—
Term → Transient tachypnea of newborn
cause/notable finding/tx
—
Postterm (>42w) →
dx/tx
Surfactant deficiency = small lung volumes
Cx: Retinopathy, Broncho-dysplasia, ICH
Tx: oxygen + surfactant
—
fluid remains in lung fissures
s/t C-section
no hypoxia
Tx: Supportive care
—
Meconium aspiration syndrome
Tx: Supportive care
Stages of labor
stage 1 (cervical ripening)
Latent ( ___ cm)
Null: <20h
Multi: <14h
Active (___ cm)
Null: ≥ __ cm/h
Multi: ≥ __ cm/h
stage 2 (fetal delivery)
Null: <3h
Multi: <2h
stage 3 (placental delivery)
Null + Multi: < 30min
stage 1 (cervical ripening)
Latent (0–6 cm)
Null: <20h
Multi: <14h
Active (6–10cm)
Null: ≥1.2cm/h
Multi: ≥1.5cm/h
stage 2 (fetal delivery)
Null: <3h
Multi: <2h
stage 3 (placental delivery)
Null + Multi: < 30min
ToF
4 findings
Pulmonary stenosis
s/t Overriding aorta
RV hypertrophy (drains R & L ventricle)
s/t VSD