HY Review #2 Flashcards

1
Q

Epigastric pain radiating to the back
Dx/ATx/ChTx?

A

acute pancreatitis

Acute
1st Normal Saline
NSAIDs → Hydromorphone
NGT → Start early Oral feeding as soon as tolerated

Chronic
Insulin (likely has DM)
Pancreo-lipase (pancreatic enzyme replacement therapy)

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2
Q

Imaging finding in Pancreatitis

A

Calcifications in Pancreas

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3
Q

Bad prognostic factors in pancreatitis?
(3)

A

Very High Wbc (>16k)
Low Hb
Hypocalcemia

Indicate → Hemorrhagic Pancreatitis

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4
Q

HTN that has remained poorly responsive to amlodipine, HCTZ, and prazosin therapy.
Labs are notable for: K 2.9L, Bicarb 29H, and Na 139.
Dx/Tx?

A

Conn Syndrome
(Primary hyperaldosteronism s/t adrenal adenoma)

Tx based if unilateral or bilateral
Unilateral ↑ Aldosterone on adrenal vein sampling: → unilateral adrenalectomy

Bilateral → MR antagonist (Spironolactone/Eplerenone)

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5
Q

In Primary hyperaldosteronism (s/t adrenal adenoma)
Renin levels: ___
Angiotensin 1 and 2 levels: ___
PAC/PRA: ___
Response to saline infusion: ___

A

↓ Renin
↓ Ang I & II
↑ >30 (High Aldo/Low Renin = High ratio)

Saline will not suppress aldosterone levels (Diagnostic)

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6
Q

BP is 250/140 with AMS.
NBSIM?

A

HTN emergency
Clevidipine, Nicardipine, Nitroprusside, Labetalol, or
Phentolamine (alpha 1 blocker)

(HTN urgency = no end organ dmg. same tx)

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7
Q

SBO + air in the wall of the biliary tree (Pneumobilia)
Dx/Tx?

A

Gallstone illeus
Entero-lithotomy (incise terminal illeum)

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8
Q

Hypodense hepatic mass with peripheral enhancement (Halo) on arterial phase and centripetal filling on delayed phases.
Dx/NBSIM?

A

Hepatic hemangioma

Liver finding that YOU DO NOT TOUCH

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9
Q

Stellate scar on liver seen abdominal CT
Dx/NBSIM?

A

Focal nodular hyperplasia
DO NOT TOUCH MASS

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10
Q

Heterogeneous enhancement in Liver on CT.
Dx/NBSIM?

A

Hepatic adenoma
Avoid Estrogen containing contraceptives
DO NOT TOUCH

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11
Q

Animal/Human Bite wound
NBSIM?

A

Debride (clean)
Amoxicillin

→ DO NOT stitch closed bc anaerobes present
→allow to heal via secondary intention

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12
Q

MCCOD in refeeding syndrome?

A

HYPOPHOSPHATEMIA

(causes cardiac problems)

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13
Q

RUQ pain, direct hyperbilirubinemia & scleral icterus (jaundiced).
No fever
Dx/NBSIM/Tx (2)?

A

Choledocolithiasis
RUQ abd U/S
If CBD dilated → ERCP → Cholecystectomy

(stone obstructs bile duct trapping bilirubin → jaundice)

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14
Q

RUQ pain, direct hyperbilirubinemia (jaundiced) & FEVER
± AMS & Hypotension
Dx/Tx (2)?

A

Acute Cholangitis
ERCP (diagnostic and therapeutic ) + Ceftriaxone

(Ascending biliary tract infection)

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15
Q

RUQ pain and FEVER
Winces upon deep palpation of the RUQ.
Labs: ↑ wbcs, mild↑AST/ALT
normal bilirubin, ALP/GGT
Dx/Tx?

A

Acute Cholecystitis
RUQ U/S
Cholecystectomy

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16
Q

pt with 30 pack year smoking history with rapidly developing digital clubbing and diffuse joint pain
Dx/NBSIM?

A

Hypertrophic Pulmonary Osteoarthropathy
Chest CT (r/o likely lung cancer; paraneoplastic)

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17
Q

Small Cell Lung Cancer Paraneoplastic Complications:
SIADH causes ____.
Lambert Eaton Myasthenia Syndrome ____.
Bonus: can also cause ____

A

SIADH → Hyponatremic seizures

LEMS → Proximal muscle weakness
(Difficulty combing hair/raising from chair)

Hypercortisolism (Cushing’s Syndrome)

auto anti-bodies against PRE synaptic voltage gated Ca channels

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18
Q

Facial swelling, headaches, and bilateral JVD
Dx/Tx?

A

SVC syndrome
EMERGENT RADIOTHERAPY

(SVC external compression from tumor)

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19
Q

2 mm L sided pupils with a droopy eyelid and L sided hand (or shoulder) pain.
Dx s/t ___

A

Horner Syndrome
s/t Pancoast Tumor ( aka Superior Sulcus Tumor)

Tumor compresses cervical sympathetic chain

TIP: Always check the apical lung tumor in smokers CXR

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20
Q

NBSIM in lung nodule seen on CXR

A

Chest CT

(don’t bother with the old CXR)

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21
Q

How to biopsy Central Lung lesions:

A

Endobronchial ultrasound + biopsy
or
Mediastinoscopy + biopsy

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22
Q

How to biopsy Peripheral Lung lesions?

A

percutaneous CT guided biopsy

(if lesion on the outer edge)

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23
Q

Pt with lung nodule on CXR and pleural effusion
NBSIM?

A

Thoracentesis (w/ cytology)

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24
Q

Where to insert needle when doing a
1. Thoracentesis
2. Nerve Block

A
  1. ABOVE the rib to avoid intercostal bundle under the rib
  2. BELOW the rib to reach the intercostal bundle
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25
Pt has thickened lung pleura and/or hemorrhagic pleural effusions Dx?
Mesothelioma (cancer of pleura) (+) **Psammoma bodies** (concentric, lamellated microscopic calcifications)
26
Squamous Cell Lung Cancer treatement?
Chemotherapy only (all other lung cancers can have any treatment)
27
Major determinant of successful TB tx?
Medication Adherence
28
Pt presents with (+) TB skin test, but **negative** chest X-ray. NBSIM?
Latent TB Isoniazid + Vit B6 (9m)
29
Asymptomatic patient with INR of 9 on Warfarin NBSIM?
prothrombin complex concentrate (PCC) ± oral vitamin K
30
Pt presents with abdominal pain Takes chronic Warfarin Labs: ↓ Hgb 9 & INR 9 Dx?
Intra-abdominal hematoma
31
65M with 6 mo history of progressively worsening dyspnea, dry cough, and bibasilar **fine crackles** heard on lung auscultation. Dx/NBSIM?
Idopathic pulmonary fibrosis High Resolution CT Chest (on NBME: **Fine crackles = Fibrotic lung disease**)
32
60M with 1 week h/o of blurry vision and severe headache. PE shows splenomegaly and markedly swollen/tender hand & feet joints with overlying erythema. Labs: ↓↓↓ Hgb (6.5), ↑↑↑ Plts (900k), ↓↓ WBC (1.2K) Dx/Tx(2)?
Essential Thrombocytosis Platelet-pharesis + Aspirin (JAK 2 mutation; hypercoagulable) – Only one cell line is absurdly high, while **all** others are low → think **myeloproliferative** d/o
33
60M 3 week of worsening pruritus (not improved with diphenhydramine) & worse when showering. PE shows flushed/roddy pt & spelnomegaly Labs: ↑↑↑ Hct (70%) Dx/Tx?
Polycythemia Vera (PV) **Phlebotomy** In PV: ↓EPO b/c negative feedback from ↑Hct (vs paraneoplastic 2º polycythemia where EPO is incr.) **Myeloproliferative d/o + JAK 2 mutation** • PV • Essential Thrombocythemia • Myelofribrosis (dry tap/teardrop rbcs)
34
List 2 common causes of Budd Chiari Syndrome on NBMEs
**P**olycythemia **V**era **PNH** (Paroxysmal Nocturnal Hemoglobinuria)
35
Intermittent & fatigable proximal muscle weakness (initial evaluation may be normal bc comes & goes) worsens with repetitive/prolonged motions improves with rest ± ocular/oral sxs Dx/Tx
**Myastenia Gravis** **Pyridostigmine** (AChE inhibitors) Auto-ABs to **postsynaptic** acetylcholine receptors of NMJ Myasthenic crisis → exacerbation leads to respiratory failure tx: serial spirometry + IVIg or **plasma exchange**
36
Elderly pt presents with Fever + acute LLQ abd pain + change in bowel movements. Leukocytosis Dx/NBSIM/Tx(2)?
Diverticulitis CT A/P **Peritoneal sxs → Colectomy** sigmoid Conservative (bowel rest & analgesia) or **FQ+Metronidazole**
37
Elderly pt presents with acute LLQ abd pain & bloody diarrhea low-grade fever + mild Leukocytosis Recent hx of MI or A-fib Dx/tx (3)?
Ischemic Colitis (supportive care + Abxs + anticoagulation)
38
Opioid adverse side effects include (3): Miosis (Constricted pupils) Sedation (AMS) Hypotension
**C**onstipation **B**radycardia **D**epressed respiratory drive **Mnemonic: MS. CBD** Normal rate of Respiration: **12 –16** bpm
39
Elderly woman presents with painless gross hematuria. UA significant for many RBCs pHpf. Cytoscopy reveals bladder mass Dx/BRF?
Transitional cell carcinoma of the Bladder (mc urinary tract tumor) presents with painless gross hematuria BRFs: **Smoking**, **cyclophosphamide** & aniline dyes (to **dye fabric**, leather, and wood. **Rubber** manufacturing)
40
Pelvic unstable s/p MVC Ecchymosis over the pelvis and scrotum Blood at the urethral meatus NBSIM?
Retrograde Urethrography Urethral Injury ━ Urethral injury diagnosis is confirmed via retrograde urethrography before bladder decompression via **supra-pubic catheter** (if complete urethral injury) ± surgery.
41
Pelvic unstable s/p MVC Gross hematuria **no** blood at urethral meatus Dx & Confirmatory test?
**Cystography** is used to evaluate suspected **Bladder rupture**
42
Compare Myasthenia Gravis to Lambert Eaton ABs to what? Repetitive use causes?
MG: * Fatiguable muscle weakness worse at end of day * muscle strength **worsens with increased** use & **improves w/ rest** * Antibodies to **postsynaptic ACh Receptors** → impaired acetylcholine release in the NMJ ─ LE: * Proximal muscle weakness * muscle strength **improves with repetitive** or ongoing use * Autoantibodies to **presynaptic** voltage-gated **calcium channels** → impaired acetylcholine release in the NMJ
43
RUQ abdominal pain + 1. No Fever + Jaundice (↑ Bilirubin) 2. **Fever** + Jaundice (↑ Bilirubin) 3. No Fever + No Jaundice (nl Bilirubin) 4. **Fever** + No Jaundice (nl Bilirubin) NBSIM → RUQ abdominal U/S
1. Choledocolithiasis → ± ERCP & Cholecystectomy 2. Acute Cholangitis → ERCP 3. Cholelithiasis → schedule elective Lap-Chole 4. Acute Cholecystitis → Cholecystectomy
44
25M with Psych sxs (Depression, Dementia, etc) Found to have Hepatomegaly & ↑ LFTs ↓ serum ceruloplasmin ± parkinsonism Dx/Tx?
Wilson disease (HepatoLenticular degeneration) **Penicillamine** (chelating agent) Impaired copper excretion → copper accumulates & deposits in the liver, brain, & eyes good prognosis if found/treated early Kayser-Fleischer rings: brown copper deposits near iris & ↑ urinary copper excretion
45
87M war-vet 6m, Dyspnea Lung bx → brown dumb bells (ferruginous bodies) dx/PFT pattern?
Asbestosis –Osis = Restrictive Lung Disease F:F ↑/– (↑F1 & ↓Fc) A-a: ↑ ↓ lung residual volume ↓ complaince =↑ elastance
46
Pt w/ well controlled history of Asthma receives treatment for acute MI in ED Has now developed shortness of breath Why?
s/t **Beta Blocker** for MI in Asthmatic **Not s/t Aspirin** bc pt doesn’t have **nasal polyps** or h/o worsening **asthma with NSAIDs**. ─ Generally try to *avoid* beta blockers in asthmatics, but this was an MI so risk/benefit.
47
35F with 8m h/o SOB now worsening + R heart strain + High Pulm Artery pressures dx/tx (3)?
Idiopathic pulmonary HTN Bosentan, Ambrisentan (endothelin receptor antagonist) Sildenafil (PDE inhibitor) ─── s/t BMPR2 mutation Excess smooth muscle proliferation in arteries
48
49M presenting for erectile dysfunction MEDS: Prazosin, Metformin, Lisinopril NBSIM?
**avoid** Sildenafil (PDE inhibitor) which is usually tx for ED BUT this pt is on Prazosin (Vasodilator) both these drugs combined will **tank BP**
49
33F presents with severe bleeding from her nose. Started after she tried to “clean out” her nose. PMH: severe allergies (on fexofenadine) Dx: BRF: Immediate NBSIM: Most common type: What if pt also had **Hemoptysis/Significant hemorrhage**: Despite initial measures, the patient’s nose continues to bleed profusely. NBSIM?
Epistaxis BRF: nose picking Tx: Apply pressure to the nose MC Type: Anterior nose bleed from Kissel-bach plexus Hemoptysis present: **Posterior** nose bleed Persistent bleeding → Electrocautery
50
Potential nasal packing complication: Genetic cause causing recurrent nose bleeds:
Toxic shock syndrome (s/t nasal packing) Hereditary hemorrhagic telangiectasia (AD) (aka Osler-Weber-Rendu syndrome)
51
Hereditary hemorrhagic telangiectasia (AD) (aka Osler-Weber-Rendu syndrome) HY Cardiovascular complication/mechanism?
High-Output Heart Failure AV malformations result in limited capillaries for gas exchange → tissue hypoxia → triggers ↑ cardiac output → chronically this results in HOHF
52
44M w/ PNA develops Polyuria, Polydipsia, dry mucus membranes Hyponatremia Hyperglycemic (**>600**) Dx/Tx (specify 1st & 2nd step)
HHS (Hyperosmolar Hyperglycemic State) **Step 1→ Normal Saline** Step 2 → Insulin infusion
53
K+ regimen rules in HHS (K+ range → 3.5 – 5.0) Group 1: Group 2: Group 3:
< 3.3 → give K+ & NS (No insulin) 3.3 – 5.5 → give K+, NS, & Insulin > 5.5 → give NS & Insulin (No K+)
54
Per the NBME, how can DM be diagnosed? Method 1 Method 2: Method 3: Method 4: Can DM be diagnosed on the basis of 1 test result?
* Fasting BGL > 125 * A1c > 6.5% * Oral Glucose Tolerance Test + BGL > 199 (Most Sensitive) * Polyuria & Polydipsia + BGL > 199 No, Diagnosis requires repeat testing on a another day (except for A1c test)
55
Per the NBME, how can T1DM be differentiated from early T2DM by way of C-peptide levels?
T↓DM = ↓ C-peptide T2DM = ↑ C-peptide ──── (↑ bc making lots of insulin that's being resisted)
56
**Macro**vascular complications of DM: (4) **Micro**vascular complications of DM: (3) ──── Best method for reducing the **micro**vascular cx of DM?
Macro → MI, PE, DVT, Stroke Micro → Neuropathy, Retinopathy, Nephropathy ──── ↓ Micro Cx → **Tight Glycemic control**
57
What kind of DM has the strongest genetic concordance? Strongest **predictor of progression** to diabetic nephropathy ? Screening in T1DM vs T2DM? How When Frequency Management of diabetic nephropathy?
Genetic → T2DM Predictor → **Microalbuminuria** **Urine albumin to creatinine ratio** (>30 = albuminuria) T1DM Urine alb:cr → 5 years after dx T2DM Urine alb:cr → at the time of dx For both screen → Annually Tx → ACE-I/ ARBs
58
MCC of ESRD in the US:
T2DM
59
32M with a h/o T1DM 3 week h/o of numbness in his bilateral feet. Shake his feet a few times to feel better. Dx: Tx, if painful: Screening guideline in T1DM: Screening guideline in T2DM: Screening intervals: Collapsed midfoot arch on foot XR:
Diabetic neuropathy Tx: **Pregabalin**, Gabapentin, TCA, SNRIs (**Duloxetine**) ── T1DM: → screen 5 years after dx T2DM: →screen at the time of dx Screen **Annually** ── Collapsed midfoot arch: →Charcot joint s/t neuropathy (Flat foot & Mal-aligned)
60
T2DM patient develops a foot ulcer. A sterile probe through the ulcer goes all the way to bone. Dx/Bugs?
Osteomyelitis Polymicrobes
61
51M h/o poorly controlled DM with a 6 mo hx of impaired vision. Dx: Screening guideline in T1DM: Screening guideline in T2DM: Screening intervals:
DM retinopathy T1DM: → screen 5 years after dx Screening guideline in T2DM: → screen at time of dx Screening intervals: Yearly
62
What is the MC complication of DM?
DM Neuropathy
63
A diabetic male goes to ophthalmologist for preventive screening. What is the most likely dx given fundoscopic exam findings? Cotton wool spots: Neo-vascularization: Tx for Neo-vascularization:
Cotton wool spots →Non-proliferative retinopathy Neo-Vasc → Proliferative retinopathy Tx for Neo-Vasc → **Laser photocoagulation** (never use VEG-F inhibitors on test)
64
Sudden onset, painless vision loss in a diabetic:
Retinal detachment
65
Abdominal pain radiating from the mid back in a band like distribution:
Thoracic Poly-radiculopathy
66
Tx for difficulty maintaining a steady erection:
Sildenafil
67
55M h/o poorly controlled T2DM 3 mo hx of N/V and a “fullness” after small meals. Abdominal imaging reveals no evidence of obstruction. Dx: Tx (2):
Gastric Paresis (Stomach Neuropathy) Metoclopramide (D2 blocker- EPS effects) Erythromycin (**Motilin agonist**)
68
What kind of diabetic should get a statin?
>40 yo
69
Contraindications to using Hb-A1c test?
Hemolytic anemia (rbcs don’t live long)
70
First line tx for T2DM: Contraindications to this Med:
Weight loss + Metformin Contraindications: Liver or Kidney disease (if getting contrast for imaging hold metformin)
71
DM drugs and their side effects Highest risk of hypoglycemia: Weight gain: Weight loss: Flatulence and diarrhea:
Hypoglycemia→sulfonylureas (-rides) Weight gain → sulfonylureas Weight loss → SGLT2-I (-ozins) & GLP-1 agonist (liraglutide, Exenatide, -tides) Flatulence and diarrhea → 𝛼- glucosidase inhibitors (Acarbose, Miglitol)
72
DM drugs and their side effects Contraindicated in ischemic cardiomyopathy: Necrotizing fasciitis of the perineum: UTIs: Bicarb of 4 (from lactic acidosis):
c/i in cardiomyopathy → TZDs (-glitizones cause fluid retention) Nec fasc of perineum → SGLT2-I UTIs: → SGLT2-I Lactic acidosis → Metformin
73
DM drugs and their mechanisms of action K channel blocker: Decreases hepatic gluconeogenesis: PPAR ɣ activators (↑ glucose uptake):
K channel blocker → Sulfonylureas ↓Gluconeogenesis → Metformin PPAR ɣ → Thiazolidinedione
74
History of MEN2A/B Contraindicated Diabetes Medications? (2)
GLP-1 agonist (–tides) DPP4 inhibitors (–gliptins)
75
Autoantibodies in T1DM (3)
anti-Glutamate Decarboxylase (GAD) Anti-Insulin Anti-Islet polypeptide
76
No Question. Just look at it.
Now look at this
77
Epidemiology Mnemonic for Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis
**PBC** → Ursodiol & anti-mitochondrial antibodies (AMA) Intrahepatic bile duct affected **PSC** → Liver Transplant & P-Anca Extrahepatic + Intrahepatic bile duct affected Confirm dx → MRCP/ERCP
78
Butterfly rash beneath the nose/lower lip that worsens with sun exposure + chronic joint pain. ──── Dx/Tx: Rapid ↑ Cr NBSIM: ──── Hb is 8 & + Coombs test:
SLE Hydroxychloroquine Renal Biopsy (Lupus nephritis) ──── Auto-immune Hemolytic Anemia (T2HSR s/t ABs against own blood)
79
33F with 3 day h/o dyspnea and abdominal pain. s/p Cardiac Transplant 8 weeks ago for sarcoidosis PE → JVD + S3 Labs & EKG normal Dx/NBSIM?
Clearly, the something is wrong with her **new heart** She got it 2m ago and now it is not working (**heart failure**) Dx: Acute Rejection → Biopsy heart (Echo guided) (less than year)
80
Perioral cyanosis + normal SaO2? dx/tx (3)/drugs causing this (3)? BRF?
Methemoglobinemia (drug induced) * TMP-SMX *  Nitrates (for MI/Chest pain) → **BRF** * Dapsone (for leprosy or dermatitis herpetiformis) Methylene blue + vit C + Cimetidine (H2 blocker)
81
What is the biggest RF for ARDS? What is the biggest RF for DIC? BRF Vit K deficiency in hospitalized pt (bleeding gums/nose)?
Sepsis Sepsis Broad-spectrum ABX
82
BRF bladder CA (**transitional** cell carcinoma) BRF for **squamous** cell bladder cancer
Smoking Schistosoma haematobium
83
What's the BRF Budd Chiari s/t hepatic vein thrombosis
Polycythemia vera (PNH is a cause, but not BRF. Other causes are hyper-coagulable states)
84
**Renal Cell Carcinoma** Paraneoplastic syndrome → Can cause → Histology → Most likely mets → Most important predictor of prognosis →
Paraneoplastic→ EPO ↑ Hct Causes → L varicocele Histology → clear cells Mets → lungs Pprognosis = **renal vein** involvement to systemic circulation
85
OSA (obstructive sleep apnea) BRF by age Kid → Adults →
Kid → adenotonsillar hypertrophy Adults → obesity
86
MCC of CAH = **21 Hydroxylase deficiency** **HY overall Lab finding** __ Aldosterone (associated 3 labs?) __ Cortisol = (associated symptom?) __ DHEA * Girls → ____ * Boys → ____
↑ ↑ **17 Hydroxy Progesterone** ↓ **Aldosterone** (hyponatremia, hyperkalemia, met acidosis) ---- ↓ **Cortisol** (Hyperpigmentation s/t ↑ MSH/ACTH) ----- ↑ ↑ **DHEA** Girl → Virilized Boys → Super boys (peripheral precocious puberty)
87
Mirena IUD (Progestin) thickens cervical mucus c/i (2)
Breast cancer hx STI <6m ago
88
Copper IUD oxidizes sperms c/i (3)
Wilson disease (copper excess d/o) STI <6m ago heavy menses hx
89
REVIEW: **Total cycle length** (–) 14 (luteal phase length) = follicular phase length
Total cycle length (–) 14 (luteal phase length) = follicular phase length
90
Pt gets biopsy on day X of cycle how do you know if pt was in the follicular (proliferative) vs luteal (secretory) phase
(use the math to figure out what phase pt was in) ---- **Total cycle length** (–) 14 (luteal phase length) = follicular phase length If X is in last 14 days of cycle → luteal phase ex: 30 day cycle → 1-16d Follicular & 17-30 Luteal)
91
Withdrawal/ Challenge test: to localize amenorrhea P2 given & w/d bleeds = (+) test No w/d bleeding after P2 = (–) test → NBSIM?
give E2 then P2 and see if they w/d bleed then
92
Pt receives P2 and has w/d bleeding why?
Anovulation (ex: PCOS)
93
Pt receives E2 then P2 and has w/d bleeding why?
Estrogen deficiency (Ex: Turner syndrome & Primary Ovarian Failure: ovaries don't work don’t make E2 or P2 so *both will be low*.)
94
Pt receives P2 and does not w/d bleed. Pt then receives E2 & P2 and still does not bleed why?
Decidua Basalis (endometrial stem cells) are missing (Ex: **Asherman** syndrome (Synechial) s/t recurrent dilation and curettage → scrape off stem cells)
95
3 Causes of **bilious** emesis → get **upper GI series** **Duodenal** Atresia → ___ Bubble **Jejunal** Atresia → ___ Bubble **Midgut** volvulus → Mal-rotation of midgut around ___
Duodenal = Double Jejunum = Triple Malrotation around **SMA**
96
Meckle’s diverticulum failed obliteration of the ___ (terminal illeum) **Painless bloody** stools In first few years of life s/t ___ mucosa **dxt/tx?**
vitelline duct ectopic gastric mucosa Dxt: TC-99m scan (Meckle’s scan) Tx: Surgery