Pregnancy

Question 1

state 3 stages in the ovarian cycle

Answer 1

1. follicular growth
2. ovulation
3. luteal function

Question 2

what is high at each of the following stages:

1. follicular growth
2. ovulation
3. luteal function

Answer 2

1. follicular growth - OESTRADIOL
2. ovulation - LH
3. luteal function - PROGESTERONE

Question 3

follicle secretes _____________ but if fertilised, it implants and becomes the corpus lute which secretes _____________

Answer 3

follicle secretes OESTRADIOL but if fertilised, it implants and becomes the corpus lute which secretes PROGESTERONE

Question 4

the corpus luteum eventually becomes the _________ which secretes _ hormones in which _________ develops breast tissue for breast milk lactation

Answer 4

the corpus luteum eventually becomes the PLACENTA which secretes 3 hormones in which PROLACTIN develops breast tissue for breast milk lactation

Question 5

name the 3 possible types of diabetes in pregnancy

Answer 5

T1DM
T2DM
GDM (3rd trimester when placenta significantly grows)

Question 6

what week does foetal organogenesis occur?

Answer 6

week 5

Question 7

another word for large baby?

Answer 7

macrosomia

Question 8

3 possible complications of a neonate?

Answer 8

respiratory distress - immature lungs

hypoglycaemia - fits

hypocalcaemia - fits

Question 9

management of T1DM and T2DM in pregnant women?

Answer 9

folic acid 5mg (very low)

regular eye checks

Question 10

what drug should you avoid for HBP in pregnancy?

Answer 10

ACEI and statins

use labetalol instead

Question 11

T1DM drug?

T2DM drug?

GDM drug?

Answer 11

T1DM drug - insulin

T2DM drug - metformin and probably insulin later

GDM drug - lifestyle, metformin and may need insulin

Question 12

if someone with hypothyroidism becomes pregnant, you must ________ the dose of thyroxine by 25mg

Answer 12

if someone with hypothyroidism becomes pregnant, you must INCREASE the dose of thyroxine by 25mg

Question 13

hCG increases __________ which suppresses ___

Answer 13

hCG increases THYROXINE which suppresses TSH

Question 14

hCG causes increased T4 and lowers TSH but causes _____________ ___________ (sickness of pregnancy)

Answer 14

hCG causes increased T4 and lowers TSH but causes HYPEREMESIS GRAVIDARUM (sickness of pregnancy)

Question 15

Infertility
Spontaneous miscarriage
Stillbirth
Thyroid crisis in labour

Transient Neonatal thyrotoxicosis

can all occur in what?

Answer 15

hyperthyroidism

Question 16

hyperthyroid management in pregnancy?

Answer 16

wait and see

beta-blockers if needed

low dose ATDs:
propylthiouracil 1st trimester
carbimazole in 2/3rd trimester

Question 17

what drug can cause the following:

embryopathy in 1st trimeter
scalp abnormalities
GI abnormalities
choanal & oesophageal atresia

Answer 17

carbimazole

Question 18

what drug can cause the following:

liver toxicity

Answer 18

propylthiouracil

Question 19

TRAb antibodies can cross the placenta and cause what?

Answer 19

neonatal transient hyperthyroidism

Question 20

pregnant female at 10 weeks gestation:

high T4
high T3
low TSH

diagnosis?

Answer 20

hyperemesis