PREFI: NERVOUS SYSTEM Flashcards
Most complex system formed by a network of nerve cells (neurons) assisted by many more supporting cells (glial cells)
NERVOUS SYSTEM
CNS IS CONSIST OF?
BRAIN AND SPINAL CORD
white matter?
axons predominate
grey matter?
neuronal perikaryal predominates
PERIPHERAL NERVOUS SYSTEM IS CONSIST OF?
cranial, spinal, and peripheral nerves; ganglia
FUNCTIONAL DIVISION
a. Somatic: sensory input perceived
consciously
b. Visceral: sensory input not perceived
consciously
SENSORY DIVISION (afferent)
FUNCTIONAL DIVISION
a. Somatic: motor output controlled
consciously or voluntarily
b. Autonomic: motor output not
controlled consciously
MOTOR DIVISION (efferent)
gathers information
SENSORY INPUT
process and interpret sensory input; decides if action is needed
INTEGRATION
RESPONSE to integrated stimuli by activating muscles or glands
MOTOR INPUT
- Develops from the ectoderm
- Begins in 3rd-4 th week of development
NERVE TISSUE
gives rise to both spinal cord and brain
Neural plate
functional unit of nervous system
NEURONS
has one axon and two or more dendrites; most common
MULTIPOLAR NEURON
has one axon and one dendrite
BIPOLAR NEURONS
has all other sensory neurons with each having a single process
UNIPOLAR OR PSEUDOUNIPOLAR NEURONS
has many dendrites but no true axon
ANAXONIC NEURONS
- SUPPORT NEURONAL SURVIVAL and activities
- Share the same development with
neurons, from the embryonic neural plate
GLIAL CELLS
GLIAL CELLS IN THE CNS
* Unique feature: proximal regions are
reinforced with bundles of intermediate filaments (glial fibrillary acid protein)
a. Helps form the blood-brain barrier
b. Regulates the ISF composition
c. Provides structural support and
organization to the CNS
d. Assists the neuronal development
e. Replicates to occupy space of dying neurons
ASTROCYTES
TYPE OF ASTROCYTES
- long processes, ABUNDANT IN WHITE MATTER
FIBROUS ASTROCYTES
TYPE OF ASTROCYTES
- short processes, abundant in gray matter
PROTOPLASMIC ASTROCYTES
GLIAL CELLS IN THE CNS
- Lines ventricles of brain and central canal of spinal cord
- Assists in production and circulation of CSF
EPENDYMAL CELLS
GLIAL CELLS IN THE CNS
* EVENLY DISTRIBUTED within WHITE and GRAY MATTER
* Originate from circulating blood monocytes
a. Phagocytic cells moving through CNS
b. PROTECTS CNS by engulfing infectious
agents and other potentially harmful
substances
MICROGLIAL CELLSL
GLIAL CELLS IN THE CNS
* PREDOMINANT glial cell in white matter
* White color: due to lipid concentrated in the wrapped myelin sheaths
a. Myelinates and insulates CNS axons
b. Allows faster action potential propagation along axons in the CNS
OLIGODENDROCYTE
GLIAL CELLS IN THE PNS
- Electrically insulates PNS cell bodies
- Regulates nutrient and waste exchange for cell bodies in ganglia
SATELLITE CELLS
GLIAL CELLS IN THE PNS
* Found only in the PNS
* Named after Theodor Schwann
a. Surround and insulate PNS axons and myelinate those with large diameters
b. Allows faster action potential propagation along an axon in the PNS
NEUROLEMMOCYTE (SCHWANN CELLS)
Clinical Significance
- Brain tumor originating from fibrous
astrocytes - Symptoms: headaches, seizures,
nausea, vomiting, vision problems,
cognitive and behavioral changes
ASTROCYTOMA
CLINICAL SIGNIFICANCE
- Common type of dementia in the elderly, affecting both neuronal perikaryal and synapses within the cerebrum
* Functional defects are caused by neurofibrillary tangles (accumulation of
tau protein) and neuronal plaques (dense aggregates of β-amyloid protein)
Alzheimer’s disease
GLIAL CELL TYPE
Origin: neural tube
Location: CNS
Main functions: myelin production, electrical insulation
OLIGODENDROCYTE
GLIAL CELL TYPE
Origin: neural type
Location: CNS
Main functions: structural and metabolic support of neurons, especially at synapses; repair processes
ASTROCYTE
GLIAL CELL TYPE
Origin: neural type
Location: line ventricles and central canal of CNS
Main functions: aid production and movement of CSF
EPENDYMAL CELL
GLIAL CELL TYPE
Origin: bone marrow (monocyte)
Location: CNS
Main functions: defense and immune-related activities
MICROGLIA