Prednisone

Question 1

What is the mechanism of action of Predisone?

Answer 1

●Prodrug metabolised to Presnisolone by the liver.

Question 2

What are the indications of Prednisone?

Answer 2

●Bronchospasm associated with asthma or COPD.
●Croup.
●Prominent itch associated with Anaphylaxis provided all systemic signs of Anaphylaxis has resolved.
●Minor allergy associated with a rash.

Question 3

What are the contraindications of Prednisone?

Answer 3

●Known severe allergy.

Question 4

What are the cautions of Prednisone?

Answer 4

●Aged less than 5 years with asthma. Administer if there is a clear history of asthma and they have had Prednisone/Presnisolone previously.

Question 5

What is the adult oral dose of Prednisone?

Answer 5

●40mg. (Administer if patient is taking a lower dose. Advise to stop taking their own dose of Prednisone and to follow up with a GP for a dose review.)

Question 6

What are the side effects of Prednisone?

Answer 6

●Fatigue.
●Sodium/water retention. (Prolonged use may worsen Hypertension and heart failure.)
●GI reflux.