Ibuprofen

Question 1

What is the mechanism of action of Ibuprofen?

Answer 1

●Non-steriodal anti-inflammatory drug (NSAID) used for treating pain.
●Inhibits (blocks) the activity of the enzyme prostaglandin synthetase, reducing prostaglandin production reducing inflammation, pain, and fever.

Question 2

What are the indications of Ibuprofen?

Answer 2

●Mild to moderate pain, usually in combination with paracetamol.
●Moderate to severe pain, usually in combination with other medicines.

Question 3

What are the contraindications of Ibuprofen?

Answer 3

●Known severe allergy.
●Pregnancy. (Causes foetal harm during pregnancy.
Premature closure of the ductus arteriososus in 3rd trimester.)
●Sepsis, shock, or clinically significant bleeding.
●Known worsening of bronchospasm.

Question 4

What are the cautions for Ibuprofen?

Answer 4

●Taken within last 4 hours.
●Abdominal pain (risk of intra-abdominal pathology).
●75 years old or greater (renal impairment is likely).

Question 5

What is the adult dose of Ibuprofen?

Answer 5

600mg for weight over 80kgs.
400mg for weight under 80kgs.

Question 6

What are the side effects of Ibuprofen?

Answer 6

●Increased bleeding.
●Renal impairment.
●GI ulcers or GI bleed. (Associated with long term use.)