Preclinical Imaging Flashcards
1
Q
Why do we do experiments on animals?
A
Translate those findings back to the clinic
2
Q
What is the range of imaging human?
A
Range of mm
3
Q
What is each pixel?
A
mm wide
4
Q
What can you see with resolution?
A
Anatomy and structure
5
Q
What is the resolution of mouse brain?
A
~100 micrometre
6
Q
What is size of signal proportional to?
A
volume
7
Q
What happens when signal increases?
A
Magnetic field strength increases
8
Q
What is the strength of a clinical scanner?
A
2 Million nuclei in a magnetic field
2.35T
9
Q
What are the 2 configuration of nuclei change?
A
- Spin down
2. Spin up
10
Q
What is spin down?
A
Anti-parallel to magnetic field
Nuclei: -16
11
Q
What is spin up?
A
Parallel to magnetic field
Nuclei: +16
12
Q
Why is animal immobilised?
A
Minimize motion artefact in image
keep animal head still
No blurring of image
