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The Science Of Medicines (PHAR 1021) year 1 > pre formulating drug solution > Flashcards

pre formulating drug solution Flashcards

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1
Q

what is a solution?

A

‘a mixture of two or more components that form a homogonous molecular dispersion’

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2
Q

what are the units for solutions?

A

weight concentration or molarity

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3
Q

what phase is solution and what does it mean?

A
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4
Q

what is a saturated solution?

A

‘where the solute is at the limit of its solubility at a certain temperature or pressure’

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5
Q
A

phenol is 100 times mroe soluble in water than benzene

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6
Q
A

change to molecular structure effects solubility

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7
Q

what changes can effect the solubility?

A

structure of molecule
substituents on solutes

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8
Q

how do substituents effect the solubility?

A

change intermolecular forces
interactions between solutes and water

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9
Q

what are the properties of substituents?

A

either hydrophilic or hydrophobic

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10
Q
A

the position of substituents effects solubility

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11
Q

main types of solid in liquid solutions?

A
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12
Q
A

‘like dissolves like’

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13
Q

what is used to predict solubility

A

polarity

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14
Q

what are the factors involved in predicting solubility?

A
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15
Q

what is used to improve solubility?

A
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16
Q

examples of amphoteric drugs?

A
17
Q

what do amphoteric drugs?

A
18
Q

when do you use the base equation?

A

ph below isoelectric point

19
Q

when do you use the acid equation?

A

ph above isoelectric point

20
Q

what happens to the solubility of a weak base as ph increases?

A
21
Q

what happesn t solubility to weak acid as ph increases?

A
22
Q

what happens to isoelctric point as solubility increases?

A
23
Q

what is the definition of solubility?

A
24
Q

how does a solid drug get in systemic circulation?

A
25
Q

definition of diffusion?

A
26
Q

what is the driving force of diffusion/

A
27
Q

how does diffusion happen?

A
28
Q

what is ficks first law of diffusion?

A
29
Q
A

D is a constant

30
Q

what does D depend on?

A

temperature,

31
Q

what is partition?

A
32
Q

when is partitioning useful?

A
33
Q

what is partition coefficient defined as?

A
34
Q
A

‘weakly acidic drugs are more soluble in alkaline solutions than in acid’

35
Q
A

basic drugs are more soluble in acids than alkaline

36
Q

how can solubility be calculated using pKa

A
37
Q
A

The Science Of Medicines (PHAR 1021) year 1 (20 decks)

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