Biological significance Flashcards
1
Q
what are the biological significance in Log P measurements in vitro?
A
predication of biological activity
understanding of mechanism of drug action
2
Q
what does log P tell you?
A
the lipophilicity of a drug
3
Q
what does log D tell you?
A
the effect of pH on the lipophilicity
4
Q
what is most commonly used to mimic biological partition?
A
n-Octanol
5
Q
what is involved in drug action?
A
random walk to the site of action (dependent of partition coefficient)
attachment to specific drug receptor site (dependent of shape and binding properties of drug)
6
Q
what is the Hansch equation?
A
log B = k1log P + k2σ + k3Es + k4
7
Q
what does the Hansch equation show?
A
quantitative structure activity relationship
8
Q
A
