Diffusion and partition Flashcards
1
Q
what is partition?
A
‘diffusion of drug between two immiscible phases’
2
Q
equation of partition coefficient?
A
P= Co /Cw
3
Q
what does the partition coefficient mostly apply to?
A
drug mostly in its lipophilic form
unionised species
4
Q
what is the apparent partition coefficient for solute ionisation in water?
A
Papp= [HA]o / ([HA]w + [A-])
5
Q
what equation is used for weak acids?
A
Log [P/D – 1] = pH - pKa
6
Q
what equation is used for weak bases?
A
Log [P/D – 1] = pKa - pH
