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Practice Question Note Cards Flashcards

1
Q

Occurs when one allele of a gene is transcribed. This occurs during genomic imprinting in which either paternal or maternal gene is expressed, but not both

A

Monoallelic expression

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2
Q

Zinc atoms associate with domains of steroid receptor protein domains to form zinc finger that

A

Bind DNA

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3
Q

Where do pKa’s 1, 2, and 3 occur?

A

pKa 1: at 0.5 eq’s of titrant
pKa 2: at 1.5 eq’s of titrant
pKa 3: at 2.5 eq’s of titrant

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4
Q

pKa’s occur every

A

0.5 eq’s of titrant added

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5
Q

Buffer regions are approximately

A

pKa +/- 1

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6
Q

TFIIH is a general transcription factor with

A

Helicase activity

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7
Q

The binding of a steroid hormone to its receptor causes a conformational change in the receptor that uncovers its

A

Zinc finger DNA binding domain

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8
Q

Plays several key roles in ribosomes, including: recognition and positioning of tRNA and mRNA and catalyzing peptidyl transferase activity of 60S subunit

A

rRNA

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9
Q

DNA molecules made as a copy of mRNA and therefore lacking the introns that are present in the genomic DNA

-used to determine amino acid sequence of a protein by DNA sequencing or to make the protein in large quantities by cloning followed by expression

A

Complimentary DNA (cDNA)

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10
Q

cDNA is used to determine the amino acid sequence of a protein by DNA sequencing or to make the protein in large quantities by

A

Cloning

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11
Q

Expression of a specific gene is down-regulated using RNA interference

A

Gene knockdown

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12
Q

Catalyze oxidation/reduction reactions

A

Oxidoreductases

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13
Q

Catalyze the transfer of C-, N-, or P- containing groups

A

Transferases

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14
Q

Catalyze the cleavage of bonds by addition of water

A

Hydrolases

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15
Q

Catalyze cleavage of C-C, C-S, and certain C-N bonds

A

Lyases

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16
Q

Catalyze racemization of optical or geometric isomers

A

Isomerases

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17
Q

Catalyze formation of bonds between carbon and O, S, and N coupled to hydrolysis of high energy phosphates

A

Ligases

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18
Q

According to the CDC, what immunization is indicated for a baby before the baby leaves the hospital?

A

Hepatitis B

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19
Q

For people with what condition is Zostavax contraindicated?

A

HIV Infection with CD4+ count

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20
Q

When do you have to have your meningococcal an Tdap (one each) immunizations by?

A

6th grade

21
Q

How many doses of Hep B vaccine must you have by kindergarten-1st grade?

A

3

22
Q

How many doses of polio vaccine must you have by the time you get to kindergarten-1st grade?

A

3 (one must be after 4th birthday)

23
Q

Which vaccine requires 1 dose for children born after 1/1/97, given no earlier than ten years of age?

A

Meningococcal

24
Q

What are the four main immunizations indicated for all adults

A

Influenza, Tdap, Varicella, MMR, Also potentially HPV

25
Q

Vericella, Zoster, amd MMR are contraindicated for

A
  1. ) Pregnant women
  2. ) Immunocompromising condition (excluding HIV)
  3. ) HIV infected with CD4+ count
26
Q

For women, one dose of Tdap is indicated for each

A

Pregnancy

27
Q

Typically, we do not give babies MMR, Varicella, or Hep A shots until

A

12 months of age

28
Q

What are the five vaccines we give babies at 2 months?

A
  1. ) Rotavirus
  2. ) DTap
  3. ) Hib
  4. ) Pneumococcal conjugate (PCV13)
  5. ) Polio (IPV)
29
Q

Varicella, Zoster, and MMR are all

A

Live immunizations

30
Q

The interval for PCV13 followed by PPSV23 has been changed from

A

6 months to 1 year

31
Q

Meningitus B vaccine can be given to adolescents and young adults aged

A

16-23

32
Q

What are the three principles of the characteristics of the disease?

A
  1. ) Significant morbidity and mortality
  2. ) Prolonged Asymptomatic Phase
  3. ) Effective treatment available?
33
Q

What are the three principles of the characteristics of the population?

A
  1. ) High Prevalence
  2. ) Acceptance of the test
  3. ) Ability to comply/report
34
Q

What are the three principles of the characteristics of the test?

A
  1. ) Sensitivity and Specificity
  2. ) Validity and Reliability
  3. ) Cost (effectiveness)
35
Q

The reliability of mammography is not very

A

High

36
Q

What is the sensitivity and specificity of the test for the prostate specific antigen (PSA)?

A 
Sensitivity = 21%
Specificity = 91%
37
Q

Which type of prostate cancer do we want to find?

A

Type B or C (but preferentially type B)

38
Q

The prevalence of prostate cancer in 50 year olds is

A

50%

39
Q

What is the cost per life saved?

A

$50, 000

40
Q

Lipid screening for those without estrogen should begin at age

A

35

41
Q

Lipid screening for everyone at risk for CAD should begin at age

A

20

42
Q

What are four types of preventative services?

A
  1. ) Annual physicals
  2. ) Screening tests
  3. ) Immunizations
  4. ) Well-baby checkups
43
Q

What are the immunizations required to attend NJ schools?

A
  1. ) DTap
  2. ) Polio
  3. ) MMR
  4. ) Hep B
  5. ) Varicella
44
Q

What are four of the top ten causes of mortality?

A
  1. ) Cardiac
  2. ) Cancer
  3. ) COPD
  4. ) Accidents
45
Q

The proportion of people in a population who have the disease at a particular point in time

A

Point Prevalence

46
Q

The proportion of people who have the disease over a specified period of time.

A

Period Prevalence

47
Q

The proportion of a population at risk that develops the disease (new cases) over a period of time.

A

Cumulative Incidence

48
Q

The rate of new cases per the total amount of time people in the population were at risk, in this case measured as person-years. Incidence density is a measure of the incidence rate in a dynamic changing population, such as workers in a particular industry.

A

Incidence Density

BMS (62 decks)

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