Practice Question Note Cards

Question 1

Occurs when one allele of a gene is transcribed. This occurs during genomic imprinting in which either paternal or maternal gene is expressed, but not both

Answer 1

Monoallelic expression

Question 2

Zinc atoms associate with domains of steroid receptor protein domains to form zinc finger that

Answer 2

Bind DNA

Question 3

Where do pKa’s 1, 2, and 3 occur?

Answer 3

pKa 1: at 0.5 eq’s of titrant
pKa 2: at 1.5 eq’s of titrant
pKa 3: at 2.5 eq’s of titrant

Question 4

pKa’s occur every

Answer 4

0.5 eq’s of titrant added

Question 5

Buffer regions are approximately

Answer 5

pKa +/- 1

Question 6

TFIIH is a general transcription factor with

Answer 6

Helicase activity

Question 7

The binding of a steroid hormone to its receptor causes a conformational change in the receptor that uncovers its

Answer 7

Zinc finger DNA binding domain

Question 8

Plays several key roles in ribosomes, including: recognition and positioning of tRNA and mRNA and catalyzing peptidyl transferase activity of 60S subunit

Answer 8

rRNA

Question 9

DNA molecules made as a copy of mRNA and therefore lacking the introns that are present in the genomic DNA

-used to determine amino acid sequence of a protein by DNA sequencing or to make the protein in large quantities by cloning followed by expression

Answer 9

Complimentary DNA (cDNA)

Question 10

cDNA is used to determine the amino acid sequence of a protein by DNA sequencing or to make the protein in large quantities by

Answer 10

Cloning

Question 11

Expression of a specific gene is down-regulated using RNA interference

Answer 11

Gene knockdown

Question 12

Catalyze oxidation/reduction reactions

Answer 12

Oxidoreductases

Question 13

Catalyze the transfer of C-, N-, or P- containing groups

Answer 13

Transferases

Question 14

Catalyze the cleavage of bonds by addition of water

Answer 14

Hydrolases

Question 15

Catalyze cleavage of C-C, C-S, and certain C-N bonds

Answer 15

Lyases

Question 16

Catalyze racemization of optical or geometric isomers

Answer 16

Isomerases

Question 17

Catalyze formation of bonds between carbon and O, S, and N coupled to hydrolysis of high energy phosphates

Answer 17

Ligases

Question 18

According to the CDC, what immunization is indicated for a baby before the baby leaves the hospital?

Answer 18

Hepatitis B

Question 19

For people with what condition is Zostavax contraindicated?

Answer 19

HIV Infection with CD4+ count

Question 20

When do you have to have your meningococcal an Tdap (one each) immunizations by?

Answer 20

6th grade

Question 21

How many doses of Hep B vaccine must you have by kindergarten-1st grade?

Answer 21

3

Question 22

How many doses of polio vaccine must you have by the time you get to kindergarten-1st grade?

Answer 22

3 (one must be after 4th birthday)

Question 23

Which vaccine requires 1 dose for children born after 1/1/97, given no earlier than ten years of age?

Answer 23

Meningococcal

Question 24

What are the four main immunizations indicated for all adults

Answer 24

Influenza, Tdap, Varicella, MMR, Also potentially HPV

Question 25

Vericella, Zoster, amd MMR are contraindicated for

Answer 25

1. ) Pregnant women 2. ) Immunocompromising condition (excluding HIV) 3. ) HIV infected with CD4+ count

Question 26

For women, one dose of Tdap is indicated for each

Answer 26

Pregnancy

Question 27

Typically, we do not give babies MMR, Varicella, or Hep A shots until

Answer 27

12 months of age

Question 28

What are the five vaccines we give babies at 2 months?

Answer 28

1. ) Rotavirus 2. ) DTap 3. ) Hib 4. ) Pneumococcal conjugate (PCV13) 5. ) Polio (IPV)

Question 29

Varicella, Zoster, and MMR are all

Answer 29

Live immunizations

Question 30

The interval for PCV13 followed by PPSV23 has been changed from

Answer 30

6 months to 1 year

Question 31

Meningitus B vaccine can be given to adolescents and young adults aged

Answer 31

16-23

Question 32

What are the three principles of the characteristics of the disease?

Answer 32

1. ) Significant morbidity and mortality 2. ) Prolonged Asymptomatic Phase 3. ) Effective treatment available?

Question 33

What are the three principles of the characteristics of the population?

Answer 33

1. ) High Prevalence 2. ) Acceptance of the test 3. ) Ability to comply/report

Question 34

What are the three principles of the characteristics of the test?

Answer 34

1. ) Sensitivity and Specificity 2. ) Validity and Reliability 3. ) Cost (effectiveness)

Question 35

The reliability of mammography is not very

Answer 35

High

Question 36

What is the sensitivity and specificity of the test for the prostate specific antigen (PSA)?

Answer 36

``` Sensitivity = 21% Specificity = 91% ```

Question 37

Which type of prostate cancer do we want to find?

Answer 37

Type B or C (but preferentially type B)

Question 38

The prevalence of prostate cancer in 50 year olds is

Answer 38

50%

Question 39

What is the cost per life saved?

Answer 39

$50, 000

Question 40

Lipid screening for those without estrogen should begin at age

Answer 40

35

Question 41

Lipid screening for everyone at risk for CAD should begin at age

Answer 41

20

Question 42

What are four types of preventative services?

Answer 42

1. ) Annual physicals 2. ) Screening tests 3. ) Immunizations 4. ) Well-baby checkups

Question 43

What are the immunizations required to attend NJ schools?

Answer 43

1. ) DTap 2. ) Polio 3. ) MMR 4. ) Hep B 5. ) Varicella

Question 44

What are four of the top ten causes of mortality?

Answer 44

1. ) Cardiac 2. ) Cancer 3. ) COPD 4. ) Accidents

Question 45

The proportion of people in a population who have the disease at a particular point in time

Answer 45

Point Prevalence

Question 46

The proportion of people who have the disease over a specified period of time.

Answer 46

Period Prevalence

Question 47

The proportion of a population at risk that develops the disease (new cases) over a period of time.

Answer 47

Cumulative Incidence

Question 48

The rate of new cases per the total amount of time people in the population were at risk, in this case measured as person-years. Incidence density is a measure of the incidence rate in a dynamic changing population, such as workers in a particular industry.

Answer 48

Incidence Density