Poxviruses

Question 1

When are poxviruses considered as most infectious

Answer 1

1st week of rash after fever

Question 2

Portal of entry of poxviruses

Answer 2

Respiratory tract with infxn of oropharyngeal or respiratory mucosa

Question 3

Genus of poxvirus that causes disease in humans

Answer 3

Parapoxviruses

Question 4

Enveloped dsDNA (lipoprotein + core + lateral bodies), replicates in cytoplasm

Answer 4

poxviruses

Question 5

Poxviruses are characterized by

Answer 5

Disseminated rashes
Proliferative lesions
Skin nodules

Question 6

Most common form of small pox, has prodronal, eruptive and sequelae stages

Answer 6

Ordinary smallpox

**prodronal: high fever 🤒 + erythematous rash
Excitative: fever subsides + centrifugal patterned rash lesion develops
Sequelae: pockmarks, scarring, blindness??

Question 7

Occurs in previously vaccinated individuals
Fewer lesions
No fever during rash development

Answer 7

Modified type smallpox

Question 8

Marked by intense toxemia, slow development of lesions, lack of pustular stage

Answer 8

Malignant or flat type small pox

Question 9

Dusky erythema and death at 5th or 6th day, prior vaccination is not protective

Answer 9

Hemorrhagic smallpox

Question 10

Risk factor of molluscum contagiosum

Answer 10

Atopic dermatitis

Question 11

Entry of poxvirus

Answer 11

Attachment to GAGs

Question 12

Where does small pox replication occur

Answer 12

Upper Respiratory tract

Question 13

T or F: molluscum contagiosum spreads systemically

Answer 13

False, contained in the s. Lucidum

Question 14

Most preferred for isolation and detection

Answer 14

Skin lesions

Question 15

In embryonic egg inoculation where is poxvirus inoculated

Answer 15

Chorioallantoic membrane

Question 16

Immune response to small pox

Answer 16

CMI is more important