Adenovirus

Question 1

Adenovirus type involvec in adults

Answer 1

4, 8. 19

Question 2

Adenovirus tpe involved in first years of life

Answer 2

1.2.5

Question 3

Adenovirus type involved in school children

Answer 3

3 and 7

Question 4

T or F: incidence of adenovirus infxn is higher in patients undergoing bone transplant

Answer 4

True

Question 5

Non-enveloped icosahedral linear dsDNA
Replication in nucleus
Pentoprotein (detachment of cells from monolayer)
Inhibits host macromolecular synth and mRNA transport to cytoplasm

Answer 5

Adenovirus

Question 6

Target cells of adenoviruses

Answer 6

Epithelial cell linings of the lung and Other enteric organs

Question 7

Adenovirus entry

Answer 7

Receptor mediated endocytosis

• *penton protein base with alpha v protein
• *serotype specific clinical manifestation depend on difff on fibers and penton proteins

Question 8

Causes hemmorhagic cystitis

Answer 8

Group B serotype

Question 9

Causes RTIs

Answer 9

Group C serotype

Question 10

Causes epidemic keratoconjunctivitis

Answer 10

Group D

Question 11

Coxsackie-adenovirus receptor

Answer 11

ACDEF

Question 12

What sample is collected for virus isolation? And when is it collected?

Answer 12

Urine, feces, leukocytes, throat swab, eye swab CSF

During onset of clinical symptoms

Question 13

Gold standard Diagnosis which forms monolayers in test tube and inoculation of samples

Answer 13

Cell culture

**positive: CPE

Question 14

T or F: adenovirus elicits both humoral and CMI

Answer 14

Tru

*humoral: neutralizing abs target hexon